In vitro affinity for vascular 5HT2 and alpha receptors was determined for several compounds (spiperone, ketanserin, mianserin, trazodone, mepiprazole, benzoctamine, m-trifluoro-methylphenylpiperazine, m-chlorophenylpiperazine, and 1-(1-naphthyl)piperazine) known to interact with serotonin receptors. All compounds competitively inhibited 5HT2 and alpha receptors with differing degrees of select...

In the title m-terphenyl derivative, C22H17NO4, the dihedral angles between the aromatic rings of the benzoic acid-acetophenone, acetophenone-benzamide and benzoic acid-benzamide units are 45.39 (8), 48.02 (8) and 42.93 (8)°, respectively. The carbamoyl and carboxyl groups are disordered with a refined occupancy ratio of 0.558 (15):0.442 (15). In the crystal, mol-ecules are linked through O-H⋯O...

The orthogonal signal correction of Wold algorithm was introduced in this thesis, which was combined with the partial least square algorithm. Calibration model of five components of benzene, methylbenzene, chlorobenzene, benzaldehyde and acetophenone in the mixed liquid samples were developed and validated by the method of independent . The result indicated that the calibration models of the co...

Microwave-assisted reactions are an environmentally friendly approach for synthesizing organic compounds. In this study, oximation of acetylferrocene and acetophenone was conducted under both microwave irradiation conventional heating conditions. Acetylferrocene were subjected to the two conditions in various solvent mixtures, extent conversion determined by 1H nuclear magnetic resonance spectr...

The asymmetric unit of the title compound, C(18)H(18)N(2)O(2), consists of two independent mol-ecules, each of which is located about a center of inversion. The mol-ecules are not planar, showing dihedral angles of 55.84 (9) and 54.10 (8)° between the piperazinedione and the aromatic rings. The piperazine N atoms exhibit a planar configuration. The crystal packing is stabilized by inter-molecul...

The synthesis of small rings by functionalization of C(sp(3) )-H bonds remains a great challenge. We report for the first time a copper-catalyzed [1+1+1] cyclotrimerization of acetophenone derivatives under mild reaction conditions. The reaction has a broad scope for the stereoselective synthesis of cyclopropanes by trimerization of acetophenone. The developed transformation is based on an extr...

Densities ρ, Speeds of sound u, isentropic compressibilities κ s , intermolecular free lengths L f , specific acoustic impedances Z, relative association R a , intermolecular attraction α, excess molar volumes VE, excess isentropic compressibilities κ s E, excess intermolecular free lengths L f E and excess specific acoustic impedances ZE of acetophenone with ethyl cyanoacetate have been report...

Levamisole (the laevorotatory isomer of tetramisole) is a new synthetic anthelmintic. A cure rate of 91% was obtained in a series of 111 ascariasis-infected children treated with a single oral dose of the drug. The failures, who were treated with the drug a second time one week later, were all cured. In a comparative study of levamisole and piperazine citrate in a series of 100 children with as...