نتایج جستجو برای: 2dg electrophoresis

تعداد نتایج: 50889  

Journal: :Japanese journal of pharmacology 1992
S Shibata Y Kagami-ishi S Ueki S Watanabe

Effect of WEB 1881 FU (nebracetam) on hypoxia and ischemia-induced impairment of 2-deoxyglucose (2DG) uptake and CA1 field potentials induced by hypoxia and hypoxia/hypoglycemia (ischemia) in rat brain slices was evaluated and compared to the findings obtained with pentobarbital and idebenone. Hippocampal and cortical slices were exposed to 15-20 min of ischemia, and then these slices were retu...

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2009
Rebecca A Darling Sue Ritter

We examined food intake in chronically maintained decerebrate rats in response to two antimetabolic drugs known to stimulate food intake, 2-mercaptoacetate (MA) and 2-deoxy-D-glucose (2DG). MA reduces fatty acid oxidation, and 2DG reduces glucose utilization. Because previous work has shown that insulin-induced hypoglycemia increases food intake in decerebrate rats, we predicted that 2DG would ...

2015
Chao-Cheng Huang Shuo-Yu Wang Li-Ling Lin Pei-Wen Wang Ting-Ya Chen Wen-Ming Hsu Tsu-Kung Lin Chia-Wei Liou Jiin-Haur Chuang

Neuroblastoma is characterized by a wide range of clinical manifestations and associated with poor prognosis when there is amplification of MYCN oncogene or high expression of Myc oncoproteins. In a previous in vitro study, we found that glycolytic inhibitor 2-deoxyglucose (2DG) could suppress the growth of neuroblastoma cells, particularly in those with MYCN amplification. In this study, we es...

2015
Chao-Cheng Huang Shuo-Yu Wang Li-Ling Lin Pei-Wen Wang Ting-Ya Chen Wen-Ming Hsu Tsu-Kung Lin Chia-Wei Liou Jiin-Haur Chuang

Neuroblastoma is characterized by a wide range of clinical manifestations and associated with poor prognosis when there is amplification of MYCN oncogene or high expression of Myc oncoproteins. In a previous in vitro study, we found that the glycolytic inhibitor 2-deoxyglucose (2DG) could suppress the growth of neuroblastoma cells, particularly in those with MYCN amplification. In this study, w...

Journal: :Free radical biology & medicine 2008
Iman M Ahmad Maher Y Abdalla Nukhet Aykin-Burns Andrean L Simons Larry W Oberley Frederick E Domann Douglas R Spitz

Overexpression of the tumor suppressor gene, wild-type p53 (wtp53), using adenoviral vectors (Adp53) has been suggested to kill cancer cells by hydroperoxide-mediated oxidative stress [1,2] and nutrient distress induced by the glucose analog, 2-deoxyglucose (2DG), has been suggested to enhance tumor cell killing by agents that induce oxidative stress via disrupting hydroperoxide metabolism [3,4...

Journal: :The Journal of comparative neurology 1984
E R Gruberg E A Newman P H Hartline

Infrared (IR) responsive nuclei in the rattlesnake Crotalus viridis were identified by using 14C-2-deoxyglucose (2DG) and autoradiography. Following 2DG intracardial injection, the IR-sensitive pit organ was stimulated periodically with an IR stimulus for 5 hours. The nucleus of the lateral descending trigeminal tract (LTTD, the primary IR sensory nucleus) was labelled heavily with 2DG. Labelli...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1989
S L Juliano B L Whitsel M Tommerdahl S S Cheema

Despite repeated experimental demonstration that somatic stimulation leads to an intermittent, "column-like" pattern of 2-deoxyglucose (2DG) label in the somatosensory cortex, the functional significance of this pattern remains uncertain. A number of recent studies have suggested that the putative inhibitory neurotransmitter GABA may play an influential role in the cortical processing of sensor...

2008
Jing Jing

Department o f Biology, University of California at San Diego, La Jolla, CA 92093-01 16, USA Lactococcus lactis takes up glucose and the nonmetabolizable glucose analogue 2-deoxyglucose (2DG) via the phosphotransferase system and extrudes the accumulated sugar phosphates in a process apparently dependent on a cytoplasmic sugar-phosphate phosphatase. Uptake of 2DG into L. lactis vesicles was sho...

Journal: :American Journal of Physiology - Endocrinology and Metabolism 2009
John Andree Babraj Kristy Mustard Calum Sutherland Mhari C. Towler Shaui Chen Kenneth Smith Kevin Green Graham Leese David Grahame Hardie Michael J. Rennie Daniel James Cuthbertson

We demonstrated previously that, in healthy young men, 5-aminoimidazole-4-carboxamide 1-beta-d-ribofuranoside (AICAR) stimulates human muscle 2-deoxyglucose (2DG) uptake without detectable activation of muscle AMP-activated protein kinase (AMPK) but with extracellular-regulated kinase 1/2 (ERK1/2) activation. We tested whether AICAR stimulates muscle 2DG uptake in healthy older patients with or...

Journal: :Journal of bacteriology 1994
J J Ye J W Neal X Cui J Reizer M H Saier

Lactobacillus brevis takes up glucose and the nonmetabolizable glucose analog 2-deoxyglucose (2DG), as well as lactose and the nonmetabolizable lactose analoge thiomethyl beta-galactoside (TMG), via proton symport. Our earlier studies showed that TMG, previously accumulated in L. brevis cells via the lactose:H+ symporter, rapidly effluxes from L. brevis cells or vesicles upon addition of glucos...

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