Three papers in the Journal this month consider issues related to outcomes and treatment in first-episode psychosis. Crossley et al (pp. 434–439) reviewed 15 randomised controlled trials of antipsychotic treatment in first-episode psychosis and found no evidence for differences in discontinuation rates or effect on symptoms between atypical and typical antipsychotics. Clear differences in side-...

The 25th anniversary year of the Journal is an opportune time for both reflecting on the past and envisioning the future of cardiopulmonary imaging. The purpose of this special year-long feature is to provide our readers with the collective perspectives of 25 international leaders in the field regarding the following questions: 1. ‘‘What is the most influential article or advance in our special...

Statement of the Problem This study investigates the effect on the output and variability of muscular work of telling the subject that his task is "easy," "medium" or "hard," when actually the task is of uniform objective difficulty. Subjects and Apparatus The subjects were fifty men and fifty women students between the ages of eighteen and twenty-five years. The subjects of each sex were divid...

Since the development of monoclonal antibodies twenty-five years ago, researchers and biotech companies have been looking to develop therapeutic uses for them. Michael Gross looks at some of the latest efforts.

The majority of the persons in this book had the advantage of being born and raised in centers of civilization, highly cultured or politically pivotal nations. Muhammad, however, was born in the year 570, in the city of Mecca, in southern Arabia, at that time a backward area of the world, far from the centers of trade, art, and learning. Orphaned at age six, he was reared in modest surroundings...

This case study of truancy in Coventry puts into a local context a national phenomenon of considerable concern to local authorities in the last quarter of the nineteenth century. The records of parents prosecuted for their child's truancy over a twenty-five year period provided the data for analysis. It was possible to produce a profile of the truants and their families within the socio-economi...

BACKGROUND A five-level version of the EuroQol five-dimensional (EQ-5D) descriptive system (EQ-5D-5L) has been developed, but value sets based on preferences directly elicited from representative general population samples are not yet available. The objective of this study was to develop values sets for the EQ-5D-5L by means of a mapping ("crosswalk") approach to the currently available three-l...

BACKGROUND The EQ-5D is a brief, generic measure of health status that can be easily incorporated into population health surveys. There are two versions of the EQ-5D for use in adult populations, one with 3 response levels in each of the instrument's 5 dimensions (EQ-5D-3L) and one with 5 levels in each dimension (EQ-5D-5L). We compared the two versions as measures of self-reported health statu...