The paper presents an evolution of personalized courses based on genetic algorithms (PCEGA). The genetic algorithm are successfully applied in the dynamic update process of the course during the whole learning process. Under this framework of this algorithm, the target user model updates dynamically, and the courses evolve during the process. It provides a good general purpose and scalable fram...

Synchronized video and high-frequency audio recordings of two trained harbour porpoises searching for and capturing live fish were used to study swimming and echolocation behaviour. One animal repeated the tasks blindfolded. A splash generated by the fish being thrown into the pool or - in controls - by a boat hook indicated prey and stimulated search behaviour. The echolocation sequences were ...

11. Adrenocorticoid responses to infection............................................................ 149 A. Glucocorticoid hormones ...................................................................... 150 1. Urinary glucocorticoid values ........................................................... 150 2. Plasma glucocorticoid, values .............................................................

MicroRNAs (miRNAs) participate in post-transcriptional regulation by targeting the 3' untranslated region of target genes that are involved in diverse biological processes. To the best of our knowledge, the association between miR‑152 and ERBB3 in ovarian cancer remains unclear. In the present study, a negative correlation between miR‑152 and ERBB3 in ovarian cancer was observed. The luciferase...

Many bladder cancers progress to invasion with poor prognosis; new therapeutic methods are needed. We developed a cytotoxic LH-RH analog, AN-152 (AEZS-108) containing doxorubicin (DOX), for targeted therapy of cancers expressing LHRH receptors. We investigated the expression of LH-RH receptors in clinical bladder cancers and in HT-1376, J82, RT-4 and HT-1197 human bladder cancer lines. The effe...

MicroRNAs (miRNAs) are a class of small non-coding, endogenous regulatory RNAs that function by controlling gene expression at the post-transcriptional level. Using small RNA sequencing and qRT-PCR techniques, we found that the expression of miR-152 was significantly increased during lactation in the mammary glands of dairy cows producing high quality milk compared with that in cows producing l...

Aspartame is a phenylalanine containing sweetener, added to foods and drinks, which avoided in phenylketonuria (PKU). However, the amount of provided by aspartame unidentifiable from food drinks labels. We performed cross-sectional online survey aiming examine accidental consumption PKU. 206 questionnaires (58% female) were completed. 55% respondents (n = 114) adults with PKU or their parent/ca...

Tacrolimus (or FK506) and cyclosporine are key standard immunosuppressive drugs that widely used for prevention of rejection in kidney transplant patients. In Kenya, the number transplants continue to steadily rise so is use these drugs. However, little published data exists on therapeutic drug monitoring (TDM) two among patients Kenya Africa. We therefore set out review information our databas...

Abstract Aim In the UK it is not a current practice to perform early (< 3 days) CT for detection and staging of severe cases acute pancreatitis. Findings pancreatic necrosis, fat stranding intraperitoneal fluid should be included in scan report as they are important prognostic factors. Furthermore, radiological facilities available permit US examination gallbladder <24 hours diagn...