نتایج جستجو برای: 1001 nights
تعداد نتایج: 6011 فیلتر نتایج به سال:
Methadone is a long-acting opioid with considerable unexplained interindividual variability in clearance. Cytochrome P450 2B6 (CYP2B6) mediates clinical methadone clearance and metabolic inactivation via N-demethylation to 2-ethyl-1,5-dimethyl3,3-diphenylpyrrolidine (EDDP). Retrospective studies suggest that individuals with the CYP2B6*6 allelic variant have higher methadone plasma concentratio...
AT-1001 [N-(2-bromophenyl)-9-methyl-9-azabicyclo[3.3.1] nonan3-amine] is a high-affinity and highly selective ligand at a3b4 nicotinic cholinergic receptors (nAChRs) that was reported to decrease nicotine self-administration in rats. It was initially reported to be an antagonist at rat a3b4 nAChRs heterologously expressed in HEK293 cells. Here we compared AT-1001 actions at rat and humana3b4 an...
Our goal in this work has been to bring together the entertaining and flow characteristics of video game environments with proven learning theories to advance the state of the art in intelligent learning environments. We have designed and implemented an educational game, a river adventure. The adventure game design integrates the Neverwinter Nights game engine with our teachable agents system, ...
Imagine trying to count grains of rice in a cup that are shaking about, and then assume the grains are less than a nanometer long. This is akin to what David Hume and colleagues from the University of Heidelberg in Germany have recently done [1]. As reported in Physical Review Letters, by observing the light emitted from a collection of laser-cooled and trapped atoms, they can distinguish two e...
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