introduction: breast cancer is the second most common cause of brain metastasis. although patient prognosis is poor, isolated brain metastasis occasionally can be an option for treatment with curative intent in breast cancer patients. case presentation: we report a patient with invasive ductal carcinoma of the breast who developed an isolated right frontal lobe metastasis within 5 months of fin...

Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) have been associated with some drugs, particularly anticonvulsants such as phenytoin. Some authors have pointed out an increased risk of TEN/SJS when phenytoin is associated with whole brain radiotherapy. We report a patient diagnosed with breast adenocarcinoma and brain metastases that was on treatment with phenytoin and, shor...

Background/Aim: The aim of this study was to analyze the survival predictions obtained from a recent graded prognostic model developed and validated in Japan. Patients Methods: This retrospective single-institution analysis 249 patients, managed with whole-brain radiotherapy for brain metastases. sum scores calculated as Japanese study. following parameters were included: number metastases, vol...

Recommendations Radiotherapy and Surgery for Single Brain Metastasis: • Surgical excision should be considered for patients with good performance status, minimal or no evidence of extracranial disease, and a surgically accessible single brain metastasis amenable to complete excision. • Postoperative whole brain radiotherapy should be considered to reduce the risk of tumour recurrence for patien...

BACKGROUND Patients with malignant melanoma may develop brain metastases during the course of the disease, requiring radiotherapeutic treatment. In patients with 1-3 brain metastases, radiosurgery has been established as a treatment option besides surgery. For patients with 4 or more brain metastases, whole brain radiotherapy is considered the standard treatment. In certain patients with brain ...