The virion host shutoff protein (vhs) of herpes simplex virus triggers accelerated degradation of cellular and viral mRNAs while sparing other cytoplasmic RNA species. Previous work has shown that vhs forms a complex with translation initiation factor eIF4H, which displays detectable RNase activity in the absence of other viral or host proteins. However, the contributions of eIF4H and other hos...

In this paper, we extend a standard nested logit model, developing an empirically applicable dynamic structural model of consumers’ choices and producers’ pricing in an oligopolistic market for newly introduced durable products with network externalities. The model is then applied to quantitatively analyze the extent to which network externalities contributed to the de facto standardization of ...

The effect of treatment protocols including either pimobendan or ramipril on vertebral heart size (VHS) in dogs with class II-III (Scandinavian-modified NYHA system) congestive heart failure (CHF) due to myxomatous mitral valve disease (MMVD) was assessed. Radiographs from 42 dogs were analysed with 21 randomized to pimobendan and 21 to ramipril. VHS was measured prior to treatment at inclusion...

Objective- to describe the vertebral heart score (VHS) measurement in the lateral view of the clinically normal native dog in khorasan province, Iran Design- Descriptive study Animals- 30 clinically healthy native dog Material and Methods- Normal dogs in clinical, laboratory, electrocardiography and radiograph...

Molecular pathways underlying the activation of dendritic cells (DCs) in response to Herpes Simplex Virus type 1 (HSV-1) are poorly understood. Removal of the HSV virion host shut-off (vhs) protein relieves a block to DC activation observed during wild-type infection. In this study, we utilized a potent DC stimulatory HSV-1 recombinant virus lacking vhs as a tool to investigate the mechanisms i...

The difference of shown social behavior towards virtual humans and real humans has been subject to much research. Many of these studies compare virtual humans (VH) that are presented as either virtual agents controlled by a computer or as avatars controlled by real humans. In this study we directly compare VHs with real humans. Participants played an economic game against a computer-controlled ...

We have previously shown that herpes simplex virus type 1 (HSV-1) infection is associated with early destabilization/degradation of infected cell mRNAs and consequent shutoff of host protein synthesis by the activity of the virion-associated host shutoff (vhs) UL41 protein. Wild-type (wt) virus destabilized/degraded the housekeeping beta-actin and alpha-tubulin mRNAs as well host stress functio...

Viral haemorrhagic septicaemia (VHS) has been considered for many years to be a major cause of loss in the French trout industry. The high prevalence of VHS in certain geographic areas made a control strategy based on control policy unfeasible. This provided the impetus for immunoprophylaxis development that resulted in 3 successive types of vaccines: inactivated, live attenuated and recombinan...

background: the herpes simplex virus (hsv) ul41 gene product, virion host shutoff (vhs) protein, mediates the rapid degradation of both viral and cellular mrna. this ability suggests that vhs protein can be used as a suicide gene in cancer gene therapy applications. the recent reports have shown that the degradation of cellular mrna during herpes simplex infection is selective. rna containing a...