نتایج جستجو برای: u266

تعداد نتایج: 289  

Fatemeh Yari, Saeideh Milani,

Background: Microparticles (MPs) are small vesicles released from the cell membrane. Accordingly, these contain active molecules to mediate biological processes, including cell proliferation and cell cycle progression. The fusion of myeloma cell lines with immunized B lymphocytes is a critical step of hybridoma technology. MPs modulate lymphoproliferation, thereby facilitating B cell expansion ...

آقاجانی, ساناز, احسان, محسن, عامری, زهرا, غیاثی, سعیده, فارسی نژاد, علیرضا, فاطمی, احمد, پوریزدانپناه, نوشین, کاظم زاده, شیما,

چکیده سابقه و هدف تلومراز در اکثر سرطان‌های انسانی و  میلوم مالتیپل بیان می‌شود و با توجه به عدم بیان آن در سلول‌های سوماتیک، هدف قرار دادن آن یک رویکرد درمانی مؤثر برای درمان سرطان می‌باشد. هدف از مطالعه ،بررسی تاثیر مهارکننده تلومراز MST-312 ،بر آپوپتوز سلول میلومی U266 بود. مواد و روش‌ها در یک مطالعه تجربی، سلول‌های U266 با دوزهای مختلف MST-312 در زمان‌های مختلف تیمار شدند، سپس زنده مانی سل...

2015
Marek Rác Michaela Sedlářová Pavel Pospíšil

In this study, evidence is provided on the formation of electronically excited species in human multiple myeloma cells U266 in the growth medium exposed to hydrogen peroxide (H2O2). Two-dimensional imaging of ultra-weak photon emission using highly sensitive charge coupled device camera revealed that the addition of H2O2 to cell suspension caused the formation of triplet excited carbonyls (3)(R...

Journal: :The Journal of biological chemistry 1994
M Schwabe J Zhao H F Kung

The human interleukin-6 receptor (IL-6R) was differentially expressed on IL-6-dependent (U266 and SKO-007) and -independent (RPMI8226) myeloma cells as well as melanoma cells (A375-C6) that are growth-inhibited by IL-6. U266 and SKO-007 cells expressed four distinct IL-6R complexes (molecular masses of 100, 120, 145, and 165 kDa) as revealed by affinity cross-linking of iodinated IL-6. RPMI8226...

2013
Jinsil Jang Soo-Jin Jeong Hee-Young Kwon Ji Hoon Jung Eun Jung Sohn Hyo-Jung Lee Ji-Hyun Kim Sun-Hee Kim Jin Hyoung Kim Sung-Hoon Kim

Background. Combination cancer therapy is one of the attractive approaches to overcome drug resistance of cancer cells. In the present study, we investigated the synergistic effect of decursin from Angelica gigas and doxorubicin on the induction of apoptosis in three human multiple myeloma cells. Methodology/Principal Findings. Combined treatment of decursin and doxorubicin significantly exerte...

2015
My-Dung Hoang Hwa-Jeong Lee Hyun-Ju Lee Sung-Hoon Jung Nu-Ri Choi Manh-Cuong Vo Thanh-Nhan Nguyen-Pham Hyeoung-Joon Kim In-Kyu Park Je-Jung Lee

Nanoparticles in the field of dendritic cell (DC) research are emerging as a promising method of enhancing the efficacy of cancer immunotherapy. We investigated the effect of branched polyethylenimine-superparamagnetic iron oxide nanoparticles (bPEI-SPIONs) on tumor cells loaded onto DCs. The tumor antigens were prepared as follows: (1) apoptotic U266 cells with ultraviolet B (UVB) irradiation ...

Journal: :Blood 1985
M Goldstein J Hoxie D Zembryki D Matthews A I Levinson

We characterized phenotypic and functional properties of B cell lines obtained from patients with multiple myeloma to determine how well they conform to particular stages of B cell differentiation. This information is a prerequisite for using such lines as tools for studying B cell growth and the regulation thereof. Two lines, GM1312 and GM1500, expressed B1 and Ia, determinants on early B cell...

Journal: :The Journal of biological chemistry 1989
S P Sreedharan K T Kodama K E Peterson E J Goetzl

Somatostatin (SOM) is a neuroendocrine tetradecapeptide that suppresses specific functions of differentiated T-cells and antibody-producing cells. The Jurkat line of human leukemic T-cells and U266 IgE-producing human myeloma cells bound [I-Tyr11]SOM specifically. The maximal level of specific binding was attained by 1-2 h at 22 degrees C for both types of cells and reversed by 70-85% within 2-...

Journal: :Life sciences 2007
Catherine Barjot Magali Tournaire Chantal Castagnino Claire Vigor Joseph Vercauteren Jean-François Rossi

This study aims to evaluate and compare the antiproliferative and proapoptotic effects of resveratrol (trans-3,4',5-trihydoxystilbene) with two of its naturally occurring oligomers, epsilon-viniferin (a dimer) and miyabenol C (a trimer). Proliferation assays performed on myeloid and lymphoid cell lines show that the three compounds inhibit cell growth of all cell types tested, with miyabenol C ...

2018
Jin Ah Cha Hyo-Sook Song Beomku Kang Moon Nyeo Park Kyoung Sun Park Sung-Hoon Kim Bum-Sang Shim Bonglee Kim

Though Cnidium officinale Makino (COM) was known to have anti-angiogenic, anti-oxidant, neuroprotective, and anti-cancer effects, the underlying anticancer mechanism of COM using endoplasmic reticulum (ER) stress and miRNA remained unclear until now. Thus, in the current study, the inhibitory mechanism of COM in lymphoma and multiple myeloma (MM) cells was elucidated. COM exerted cytotoxicity i...

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