Two prospective studies of ingrowing toenail management were conducted. In the first, 163 patients (204 ingrowing nail edges) who had not had previous surgery were randomised and treated by total nail avulsion, nail edge excision, or nail edge excision with phenolisation of the germinal matrix; recurrence rates one year postoperatively were 73%, 73% and 9% respectively. In the second study, 63 ...

Pathogenic variants in ITGB4 cause various forms of autosomal recessive epidermolysis bullosa (EB). encodes integrin-β4, which plays a critical role the maintenance skin basement membrane integrity. Here, we aimed to delineate genetic basis dominant isolated nail dystrophy 2 families. We studied total five affected individuals with and no other cutaneous or extra-cutaneous findings. Whole exome...

Dyskeratosis Congenita (DKC) is a rare progressive bone marrow disorder associated with multi-systemic involvement. It is also characterized by triad of abnormal skin pigmentation, nail dystrophy and mucosal leukoplakia. Liver cirrhosis and portal hypertension are said to be uncommon among these patients. We hereby report a case of an adult male who presented with pancytopenia, abnormal skin pi...

A 29yearold woman presented to our clinic for subungueal hyperkeratotic lesion of the fourth left toenail. In 1997, she developed systemic sarcoidosis with lung and cutaneous lesions. The patient required gradually tapered systemic corticosteroids for 4 years and methotrexate for 1 year to control lung disease. A few months previously a hyperkeratotic verrucous lesion developed beneath the dist...

BACKGROUND There have been a few reported cases of congenital great toenail dystrophy (GTND), described as a congenital malalignment of the great toenails. However, acquired GTDN is rare, and has not been documented extensively. This study aimed to describe the clinical features of 21 patients with acquired GTND. METHODS Twenty-one patients with acquired GTND who visited Yeouido St. Mary's Ho...

Background: Subungual exostosis is a relatively uncommon, slow-growing benign bone tumor that most often affects the toes of young people and has significant impact on quality life. The treatment which essentially based surgical excision with meticulous closure wound while avoiding causes nail dystrophy.