tumor necrosis factor- α (tnf-α) plays an important role in diverse cellular events such as septic shock, induction of other cytokines, cell proliferation and apoptosis. tumor necrosis factor (tnf)-related apoptosis-inducing ligand (trail) is currently attracting great interest as a potential anticancer drug. trail could selectively induce apoptosis in tumor cells in vitro and in vivo by a deat...

background: bombesin shows high affinity for gastrin-releasing peptide (grp) receptors which over expressed on the cell surfaces of several human tumors particularly in prostate and breast cancers. the aim of this study was labeling of designed analogue with99mtc via hynic and tricine /edda and evaluation as potential targeted tumor scintigraphic agent.materials and methods: hynic-bombesin was ...

Background: Bombesin shows high affinity for Gastrin-releasing peptide (GRP) receptors which over expressed on the cell surfaces of several human tumors particularly in prostate and breast cancers. The aim of this study was labeling of designed analogue with99mTc via HYNIC and Tricine /EDDA and evaluation as potential targeted tumor scintigraphic agent. Materials and Methods: HYNIC-Bombesin wa...

One of the problems in antigen-specific cancer immunotherapy is the low density of the tumor antigen-derived peptide endogenously presented on tumor cell surface major histocompatibility complex class I molecules. To overcome this, we are engaged in research on peptide intra-tumor injection to enhance tumor cell antigenicity. In in vivo studies using immunodeficient mice, the peptide injected i...

Antimicrobial peptides, a large class of molecules synthetized by various organisms as an innate defense against pathogens are more and used for their anticancer properties well. In order to overcome some limitations enhance therapeutic efficiency, the use delivery systems was taken into consideration. this study we describe original system antimicrobial peptides based on its physico-chemical p...

Radiotherapy Sensitization Enhancing the cellular radiosensitivity is instrumental for improving efficacy of tumor radiotherapy. In article number 2206415, Junping Wang, Cheng and co-workers report a tumor-penetrating nanomaterial iCoDMSN constituted with dendritic mesoporous silica nanoparticles iRGD peptide-conjugated [email protected] nanodots. By decreasing KEAP1 expression upregulating nuc...

The human Vγ9Vδ2 T cell is a unique type that holds great potential in immunotherapy of cancer. In particular, the therapeutic this adoptive therapy (ACT) has gained interest. regard optimization vitro expansion methods and functional characterization desirable. We show cells, expanded with zoledronic acid (Zometa or ZOL) Interleukin-2 (IL-2), are efficient cancer killers trend towards increase...

Introduction Several specific tumor antigens have been defined by virtue of their immunogenicity in cancer patient5 [1,2]. In addition to the definition of specific tumor antigens, we now understand that T-cells recognize those antigens as peptides presented in the context of human major histocompatibility (MHC) molecules. These basic ob5ervatioJ15 have generated interest in the design of tumor...

Objective(s): Up to now, many researches have been performed to improve the antitumoral effect of melanoma differentiation-associated gene-7 (mda-7) protein. The purpose of our research was to construct 3 expression vectors producing mda-7 in fusion with RGD (Arginine-Glycine-Aspartic acid) peptide and evaluate their expression.     Materials and Methods: mda-7 gene with two different RGD sequ...