It is very well established that supplementation with EPA/DHA omega-3 can markedly lower fasting serum triglyceride (triacylglycerol) levels in those who are or are not receiving medication with blood cholesterol-lowering statins (Holub, Can. Medical Assoc. J., 177: 604-605 (2007)). Furthermore , omega-3 ‘concentrates’ are now commercially available in both the ‘re-esterified triacyglycerol’ (T...

In late-stage atherosclerosis, much of the cholesterol in macrophage foam cells resides within enlarged lysosomes. Similarly, human macrophages incubated in vitro with modified LDLs contain significant amounts of lysosomal free cholesterol and cholesteryl ester (CE), which disrupts lysosomal function similar to macrophages in atherosclerotic lesions. The lysosomal cholesterol cannot be removed,...

It is very well established that supplementation with EPA/DHA omega-3 can markedly lower fasting serum triglyceride (triacylglycerol) levels in those who are or are not receiving medication with blood cholesterol-lowering statins (Holub, Can. Medical Assoc. J., 177: 604-605 (2007)). Furthermore , omega-3 ‘concentrates’ are now commercially available in both the ‘re-esterified triacyglycerol’ (T...

Background. Recent data suggest that the renin-angiotensin system may be involved in triglyceride (TG) metabolism. We explored the effect of the common A1166C and C573T polymorphisms of the angiotensin II type 1 receptor (AT1R) gene on postprandial lipemia. Methods. Eighty-two subjects measured daytime capillary TG, and postprandial lipemia was estimated as incremental area under the TG curve. ...

Potentially atherogenic triglyceride-rich lipoprotein (TRL) remnants can be isolated and quantitated as remnant-like particles (RLP), using an immunoaffinity gel containing specific anti-human apolipoprotein A-I (apoA-I) and apoB-100 monoclonal antibodies. The aim of the present study was to determine the relationship between postprandial changes in RLP levels and changes in total serum triglyc...

I wish to comment on the limitations of an automated remnant lipoprotein cholesterol (RemL-C) assay reported in Clinical Chemistry (1 ). Remnants are lipoprotein particles produced after newly formed triglyceride-rich lipoproteins (TRLs) of either hepatic or intestinal origin enter the plasma space and undergo lipolysis via the action of lipoprotein lipase in the capillary bed. During this proc...

In the present study, effect of ethanolic extract of bark of Tectona grandis Linn. (TG) was evaluated using alloxan induced diabetes and associated renal complication. The diabetes was induced by administration of alloxan to the rats at the dose of 140 mg/kg, i.p. TG was administered to diabetic animals for six weeks and various biochemical parameters in blood and urine (plasma glucose, serum a...

Background & aims: Liver fat associates with postprandial hypertriglyceridemia, thus potentially contributing to postprandial triglyceride-enrichment of HDL (HDL-TG), and subsequent HDL dysfunction and finally cardiovascular disease.

objective: to study the effects of a high dose alpha-tocopherol on serum total cholesterol (tc), triglyceride (tg), and the high density lipoprotein (hdl) levels of patients with schizophrenia receiving olanzapine. method: thirty six adults diagnosed with schizophrenia based on dsm-iv who were taking olanzapine for a minimum of thirty days entered this eight-week, double blind, placebo-controll...