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In spite of extensive scientific knowledge about the neurobiological systems and neural pathways underlying addictions, only limited progress has been made to reduce the population-level incidence of addictions by using prevention and treatment programs. In this area of research, the translation of basic neuroscience of causal mechanisms to effective interventions has not been fully realized. I...

Stressors clearly contribute to addiction etiology and relapse in humans, but our understanding of specific mechanisms remains limited. Rodent models of addiction offer the power, flexibility, and precision necessary to delineate the causal role and specific mechanisms through which stressors influence alcohol and other drug use. This review describes a program of research using startle potenti...

The goal of this article is to discuss ways to further improve the search for potentially procognitive agents that could be used to enhance cognition and functional outcome in schizophrenia. In particular, we focus on the potential advantages to this process of using a contemporary, cognitive neuroscience-based approach to measuring cognitive function in clinical trials of procognitive agents i...

performance and development are based on hard work, experience and learning. learning how to change different behaviors is crucial to successful talent management plans. within the brain there are complex connected circuits that can identify threats. the brain reacts to change as a threat. there is also a collection of brain structures tied to a natural reward system that are involved in the re...

Psychological interventions are first-line treatments of depression. Despite a rich theoretical background, the mediators treatment effects remain only partially understood: it has been difficult to precisely delineate targets psychological engage, and even more differentiate amongst engaged by different interventions. Here, we outline these issues discuss surprisingly understudied approach, na...

We propose a network approach to clinical translation that defines core behavioral phenotypes of traumatic brain injury (TBI) with respect to damage to specific intrinsic connectivity networks (ICNs). We survey recent approaches to clinical translation from cognitive neuroscience that enhance network function and recovery from brain injury through interventions that deliver targeted (network sp...