Novel tolmetin derivatives 5a–f to 8a–c were designed, synthesised, and evaluated for antiproliferative activity by NCI (USA) against a panel of 60 tumour cell lines. The cytotoxic the most active 5b 5c was examined HL-60, HCT-15, UO-31 Compound found be potent derivative lines with IC50 values 10.32 ± 0.55, 6.62 0.35, 7.69 0.41 µM, respectively. Molecular modelling studies towards VEGFR-2 site...

Unusual expression of interleukin-1alpha, -1beta and -6 was previously found in the epiphyseal cartilage of rat fetuses prenatally exposed to various non-steroidal anti-inflammatory drugs (NSAID, i.e., ibuprofen, piroxicam, tolmetin) and selective cyclooxygenase-2 inhibitor (DFU). The aim of the present study was to evaluate the role of placenta in such phenomenon. Morphology of the organ, thic...

BACKGROUND Turkey reproduction is by artificial insemination using pooled semen so there is interest in storing semen. Fertilizing capacity declines after six hours storage, possibly due to poor sperm mobility. Prostaglandins (PG) affect mammalian sperm motility, but avian sperm has not been widely studied. For this study, levels of PG E1, E2, and F2 alpha in turkey seminal plasma and sperm ext...

A 67-year-old black woman with hypertension and adult-onset diabetes mellitus presented to Hermann Hospital, Houston, Tex, with complaints of intermittent chest pain and shortness of breath. She stated that 5 days before presentation she had begun walking for exercise, starting with one block, and increasing by one block daily. During the past 2 days, she noted a pressure-type pain under the le...