PURPOSE Head and neck squamous cell carcinomas exhibit variable sensitivity to inhibitors of the PI3K/mTOR pathway, an important target of genomic alterations in this cancer type. The mitogen-activated protein kinase kinase (MEK)/ERK/activator protein 1 (AP-1) and nuclear factor-κB (NF-κB) pathways are also frequently co-activated, but their roles in resistance mechanisms to PI3K/mTOR inhibitor...

Quantum computing is currently being researched in many countries, and if implemented the near future, it may pose a threat to existing encryption standards. In quantum computer environment, asymmetric can be solved by Shor’s Algorithm polynomial time, difficulty of breaking symmetric using brute force reduced from N times square root Grover’s Algorithm. We take Advanced Encryption Standard as ...

Colorectal cancer (CRC) is the third most common cancer worldwide. Metastatic progression is a primary factor contributing to lethality of CRC patients. However, the molecular mechanisms forming early local invasion and distant metastatic colonies are still unclear and the present therapeutic approaches for CRC are unsatisfactory. Therefore, novel therapies targeting metastatic invasion that co...

Hepatitis B virus (HBV) infection plays a crucial role and is a major cause of hepatocellular carcinoma (HCC) in China. microRNAs (miRNAs) have emerged as key players in hepatic steatosis and carcinogenesis. We found that down-regulation of miR-384 expression was a common event in HCC, especially HBV-related HCC. However, the possible function of miR-384 in HBV-related HCC remains unclear. The ...

20.1 Fundamentals of Network Traffic Monitoring and Analysis . . . . . . . . . . . . . . . . . . 384 20.1.1 What Are the Traffic Measurement Problems? . . . . . . . . . . . . . . . . . . . . . . . . . . 384 20.1.2 Traffic Matrix Measurement . . . . . . . . . . 385 20.1.3 Traffic VolumeMeasurement . . . . . . . . . 385 20.1.4 Traffic Dynamics Measurement . . . . . . . 385 20.1.5 Traffic Mixture ...

We previously reported the development of a simple, user-friendly, and versatile 384 hanging drop array plate for 3D spheroid culture and the importance of utilizing 3D cellular models in anti-cancer drug sensitivity testing. The 384 hanging drop array plate allows for high-throughput capabilities and offers significant improvements over existing 3D spheroid culture methods. To allow for practi...

Purpose: Head and neck squamous cell carcinomas exhibit variable sensitivity to inhibitors of the PI3K/mTOR pathway, an important target of genomic alterations in this cancer type. The mitogen-activated protein kinase kinase (MEK)/ERK/activator protein 1 (AP-1) and nuclear factor-kB (NF-kB) pathways are also frequently co-activated, but their roles in resistance mechanisms to PI3K/mTOR inhibito...

Autoradiography helps to determine the distribution and density of muscarinic receptor (MR) binding sites in the brain. However, it relies on the selectivity of radioligands toward their target. 3H-Pirenzepine is commonly believed to label predominantly M1MR, 3H-AFDX-384 is considered as M2MR selective ligand. Here we performed series of autoradiographies with 3H-AFDX-384 (2 nM), and 3H-pirenze...