background: currently available radioprotectors are poorly tolerated in man and the general use of aminothiols is compromised by their side effects. this study was carried out to test and compare the radioprotective potential of cimetidine and famotidine against lethally gamma irradiated nmri mice. materials and methods: adult male nmri mice in groups of 10 were exposed to various doses of gamm...

Non-thermal atmospheric pressure plasma has attracted great interest due to its multiple potential biomedical applications with cancer treatment being among the most urgent. To realize the clinical potential of non-thermal plasma, the exact cellular and molecular mechanisms of plasma effects must be understood. This work aimed at studying the prostate cancer specific mechanisms of non-thermal p...

purpose: in recent years high explosive bomb attacks have been increasingly directed against   civil structures by various terrorist organizations. this paper describes a numerical method for   assessing the interaction of high explosive air blast within the complex geometrical type of a   congested urban environment.   materials and methods: the first step in predicting blast effects on a targ...

The overall goal of this project was to improve the reliability of thermal process validation tools for Salmonella in pork products, by accounting for stress adaptation that can occur during slow cooking processes. The specific objectives were: (1) To modify, for ground and whole-muscle pork products, a model recently developed at MSU to predict the rate of Salmonella thermal inactivation as a ...

Hybrid lethality is a type of reproductive isolation barrier observed in two developmental stages, hybrid embryos (hybrid seeds) and seedlings. has been reported many plant species limits distant hybridization breeding including interspecific intergeneric hybridization, which increases genetic diversity contributes to produce new germplasm for agricultural purposes. Recent studies have provided...

BACKGROUND In light of the increased suicide rate in Korea, it has become important for researchers to examine the various factors associated with it. The purpose of this study is to compare and analyze the difference between suicide attempters and completers in terms of the suicide methods used and the lethality of these methods. In addition, we investigated certain demographic factors that ar...

We identified a synthetic lethality between PLK1 silencing and the expression of an oncogenic Epidermal Growth Factor Receptor, EGFRvIII. PLK1 promoted homologous recombination (HR), mitigating EGFRvIII induced oncogenic stress resulting from DNA damage accumulation. Accordingly, PLK1 inhibition enhanced the cytotoxic effects of the DNA damaging agent, temozolomide (TMZ). This effect was signif...