Cytochrome P-450 (CYP) 2D6 is responsible for the biotransformation of over 35 pharmacologic agents. In the process of studying CYP2D6 we identified phenotype-genotype discordance in two individuals receiving terbinafine. This prompted evaluation of the potential for terbinafine to inhibit CYP2D6 in vitro. Human hepatic microsomes and heterologously expressed CYP2D6 were incubated with terbinaf...

Question What is the optimum duration for oral terbinafine therapy when treating children with tinea capitis caused by Micro-sporum species? How do these terbinafine dose schedules compare in effectiveness to griseofulvin? Design: Four double-blind duration-finding terbinafine arms were compared with an unblinded griseofulvin arm. Each arm was parallel, and patients were randomly allocated. The...

Onychomycosis is a common nail infection. Terbinafine-resistant dermatophyte infections pose an emerging global public health concern, but few cases have been described in the United States. We retrospectively reviewed and characterized clinical, histopathological, mycological features of patients with mycologically confirmed onychomycosis who failed oral terbinafine treatment for at U.S. acade...

OBJECTIVE To compare the efficacy and safety of continuous terbinafine with intermittent itraconazole in the treatment of toenail onychomycosis. DESIGN Prospective, randomised, double blind, double dummy, multicentre, parallel group study lasting 72 weeks. SETTING 35 centres in six European countries. SUBJECTS 496 patients aged 18 to 75 years with a clinical and mycological diagnosis of d...

Terbinafine, a synthetic allylamine, exerts fungicidal activity against dermatophytes, the causative pathogens of tinea pedis. As proven in numerous clinical trials, tinea pedis can be effectively and safely treated by topical terbinafine. In fact, a 1-week application of terbinafine 1% cream eradicated fungal pathogens at least as effectively as 4-week treatment courses with topical azole deri...

OBJECTIVE To examine long-term cure and relapse rates after treatment with continuous terbinafine and intermittent itraconazole in onychomycosis. DESIGN Long-term prospective follow-up study. SETTING Three centers in Iceland. SUBJECTS The study population comprised 151 patients aged 18 to 75 years with a clinical and mycological diagnosis of dermatophyte toenail onychomycosis. INTERVENT...

In vitro, terbinafine is highly active against a broad spectrum of pathogenic fungi. We evaluated the activities of terbinafine and itraconazole against 31 isolates of Paracoccidioides brasiliensis. The tests were conducted by using a broth macrodilution procedure. MICs, in micrograms per milliliter, were as follows: terbinafine, 0.015 to 1.0 (geometric mean, 0.1188); itraconazole, 0.007 to 0.5...

BACKGROUND The incidence of recurrent tinea infections after oral terbinafine therapy is on the rise. AIM This study aims to identify the appearance of incomplete cure and relapse after 2-week oral terbinafine therapy in tinea corporis and/or tinea cruris. MATERIALS AND METHODS A total of 100 consecutive patients clinically and mycologically diagnosed to have tinea corporis and/or tinea cru...

The archaeal plasma membrane consists mainly of diether lipids and tetraether lipids instead of the usual ester lipids found in other organisms. Although a molecule of tetraether lipid is thought to be synthesized from two molecules of diether lipids, there is no direct information about the biosynthetic pathway(s) or intermediates of tetraether lipid biosynthesis. In this study, we examined th...

We investigated the biochemical basis for resistance in six sequential clinical isolates of Trichophyton rubrum, from the same patient, which exhibited high-level primary resistance to terbinafine. Cellular ergosterol biosynthesis was measured by incorporation of [14C]acetate, and microsomal squalene epoxidase was assayed by conversion of [3H]squalene to squalene epoxide and lanosterol. Direct ...