Orthogonal frequency division multiplexing (OFDM) combined with time division multiplexing (TDM), called OFDM/TDM, can overcome the high peak-to-average-power ratio (PAPR) problem of the conventional OFDM. Its bit error rate (BER) performance in a frequency-selective fading channel is improved by adoption of frequency-domain equalization (FDE) based on minimum mean square error (MMSE) criterion...

The Telescoping Decomposition Method (TDM) is a new iterative method to obtain numerical and analytical solutions for first order nonlinear differential equations. The method is a modified form of the well-known Adomian Decomposition Method (ADM) where the Adomian polynomials have not to be calculating. The (TDM) is easier to apply and offers better accuracy than the (ADM). Also, it can be appl...

Virtually all of the elements of Mycobacterium tuberculosis (Mtb) pathogenesis, including pro-inflammatory cytokine production, granuloma formation, cachexia, and mortality, can be induced by its predominant cell wall glycolipid, trehalose 6,6'-dimycolate (TDM/cord factor). TDM mediates these potent inflammatory responses via interactions with macrophages both in vitro and in vivo in a myeloid ...

The burden of human disease related to medically important fungal pathogens is substantial. An improved understanding of antifungal pharmacology and antifungal pharmacokinetics-pharmacodynamics has resulted in therapeutic drug monitoring (TDM) becoming a valuable adjunct to the routine administration of some antifungal agents. TDM may increase the probability of a successful outcome, prevent dr...

In the last 20 years, several prospective studies have been conducted to improve the expediencyof Therapeutic Drug Monitoring(TDM) application in the field of oncology. However, to start and maintain modern TDM services in developing countries requires more funding and education to reform clinical practices.In the present study, we aimed to determine the current practice of chemotherapy and non...

Therapeutic drug monitoring (TDM) involves the measurement of plasma or serum drug concentration to adapt dosages to achieve predefined target concentrations that are associated with optimal clinical response while minimizing the chance of encountering toxicity. Many papers in the field of antifungal drugs have focused on the evidence that supports the use of TDM thereby emphasizing the breakpo...

The ideas of textual or data mining (TDM) and subsequent analysis go back hundreds if not thousands of years. Originally carried out manually, textual and data analysis has long been a tool which has enabled new insights to be drawn from text corpora. However, for the potential benefits of TDM to be unlocked, a number of non-technological barriers need to be overcome. These include legal uncert...

Nowadays it is reiterated in the literature to put more emphasis on Transportation Demand Management (TDM) strategies rather than the traditional transportation strategies which are based on “supply-side” tactic specifically in rapidly growing developing countries. The experiences of many cities reveal that as capacity is increased, demand increases at a similar rate, and subsequently in the lo...

BACKGROUND AND OBJECTIVE Despite the availability of clinical practice guidelines (CPGs) for therapeutic drug monitoring (TDM) of vancomycin, vancomycin serum concentrations still do not reach therapeutic concentrations in many patients. Thus, we sought to systematically review the quality and consistency of recommendations for an international cohort of CPGs regarding vancomycin TDM. METHODS...

Context: Technical debt (TD) is ametaphor reflecting technical compromises that can yield short-term benefit but may hurt the long-term health of a software system. Objective: This work aims at collecting studies on TD and TDmanagement (TDM), and making a classification and thematic analysis on these studies, to obtain a comprehensive understanding on the TD concept and an overview on the curre...