A nanohybrid was prepared with an inorganic clay material, montmorillonite (MMT), for taste masking of sildenafil (SDN). To further improve the taste-masking efficiency and enhance the drug-release rate, we coated the nanohybrid of SDN-MMT with a basic polymer, polyvinylacetal diethylaminoacetate (AEA). Powder X-ray diffraction and Fourier transform infrared experiments showed that SDN was succ...

Conventional taste-masking strategies are used to overcome the bitter taste perception of pharmaceuticals by coating the drug particles and/or adding flavoring agents. However, for certain product categories such as rapid dissolve sublingual tablets, taste-masking is challenging. Programs exploring such formulation strategies in the LO-CS phase or post CS phase possess very little toxicological...

Undesirable taste is one of several important formulation problems that are encountered with certain drugs. The problem of bitter and obnoxious taste of is a challenge to the pharmacist in the present scenario. Several oral pharmaceuticals and bulking agents have unpleasant, bitter-tasting components. The desire of improved palatability in these products has prompted the development of numerous...

Sildenafil citrate is one of the most effective agents for treatment of erectile dysfunction which acts by inhibiting the cGMP-specific phosphodiesterase type 5. Extensive research work is focused on flash release dosage forms and especially fast dissolving films are successful to attract pharma-industry due to ease of preparation and opportunity to extend patent life. Films are widely acceptab...

In the present study Rizatriptan benzoate, which is the bitter drug requires taste, masking. βCyclodextrin is used in taste masking, which improves the patient compliance and also increases the rate of dissolution. Solid dispersion of drug and βCyclodextrin were prepared which was optimised in 1: 8 ratios, which gave satisfactory results for taste masking. This was then characterised using Diff...

Ofloxacin is a synthetic chemotherapeutic antibiotic used for treatment of a variety of bacterial infections, but therapy suffers from low patients' compliance due to its unpleasant taste. This study was aimed to develop taste masked microspheres of ofloxacin using Eudragit and to prepare orodispersible tablets of the formulated microspheres using natural superdisintegrant. Taste masking Eudrag...

Orodispersible dosage forms are promising new approaches for drug delivery. They enable an easy application, as there is no need to drink high amounts of liquids or swallow large solid dosage forms. The aim of the study was to develop an orodispersible film (ODF) as an alternative to tablets, syrups or suppositories for the treatment of vomiting and nausea, especially for the pediatric populati...

Taste is mainly a function of taste buds in the mouth. In the formulation for pediatric & geriatric, bed ridden & non-cooperative patients the main challenge to the compounding pharmacist is to mask the taste of obnoxious and bitter drugs, result is patient not receiving the optimal therapeutic value of their medication. Taste masking is the main factor in the development of the dosage form. It...