Hepatocyte nodules, structures consistently seen in every model of liver carcinogenesis well before the first appearance of cancer, were examined with respect to some Phase I and Phase II components considered to be important in the metabolism of carcinogens and other xenobiotics. Phase I components are those related to the metabolism of xenobiotics and include microsomal cytochromes P-450 and ...

Background: Hemidesmus indicus is an important medicinal plant and extensively used in Ayurvedic and Unani system of medicine. The aim of the study was to evaluate the antioxidant, hypoglycaemic and hypolipidemic potential of methanolic extract of roots of Hemidesmus indicus (HIE) in streptozotocin (STZ) induced diabetic mice. Methods: HIE was analyzed by LC-MS to determine its phytochemical co...

This study evaluated the effect of selenium and extracts of Gongronema latifolium on some biochemical parameters in alloxan-induced diabetic rats. Forty male albino rats equally divided into eight experimental groups were used. Two groups served as normal and diabetic control and received placebo treatment. Four diabetic test groups were treated with G. latifolium extract, glibenclamide, combin...

Propionic acid (PA) is a short chain fatty acid, a common food preservative and metabolic end product of enteric bacteria in the gut. The present study was undertaken to investigate the effect of PA on liver injury in male rats. Male western albino rats were divided into two groups. The first group served as normal control, the second was treated with PA. The activities of serum hepatospecific ...

Killer lectin-like receptor NKG2D, which is found on natural killer cells, recognizes MHC class 1-related ligands and also interacts with glycan ligands, heparin-conjugated bovine serum albumin (heparin-BSA) and sialyl Lewis X (sLeX) on multi-antennary N-glycans on transferrin secreted by HepG2 cells (HepTF). Using the glutathione-Stransferase-fused extracellular domain (AA 73-216) of NKG2D (rG...

Transcriptional activation of the soybean (Glycine max) C H Z / 4 gene (also referred to as GmhspZ6-A) and increase in abundance of the C H Z / 4 mRNA (also referred to as pCE54) have been previously shown to occur following treatment of soybean seedlings with auxins, nonauxin analogs, heavy metals, and a variety of other agents. To determine whether the G H Z / 4 promoter is responsive to an a...

Formation of small and highly reactive oxygen species (ROS) is normal phenomena in living cells. The Reactive Oxygen Species cover free radical such as superoxide (O2 ̅ ), hydroxyl (OH), perhydroxy (HO2 ̅ ) and alkoxy (RO) and non-radicals like, hydrogen peroxide (H2O2) and singlet oxygen ( O2). Their formation and reactivity is well established and found to be tightly regulated. ROS level exceed...

Copyright  2015 irjpbs. Aim of the present study is to evaluate the preventive role of phytic acid on mitochondrial lipid peroxides, antioxidants and lipids in isoproterenol (ISO)-induced myocardial infarction (MI) in male Wistar rats. Rats subcutaneously injected with ISO (85 mg/kg) at an interval of 24 h for 2 days resulted in a significant increase in the levels of mitochondrial lipid perox...

Anthocyanins are thought to have antioxidant effects in the body. The effects of two anthocyanins, malvidin and peonidin, on activity of antioxidant enzymes, glutathione-Stransferase (GST), glutathione reductase (GR), and glutathione peroxidase (GPx), were examined in HT-29 human adenocarcinoma cells. Cells were treated with each anthocyanin or a combination of both at concentrations of 0, 5, a...

A strain of house fly was collected from the Third Yumenoshima Island in Japan and selected with the pyrethroid insecticide permethrin. Resistance to permethrin evolved to >18; 400-fold in the selected (YPER) strain, and the mechanisms and genetics of resistance in this strain were examined. Permethrin resistance was decreased by pretreatment with piperonyl butoxide or 2-propynyl 2,3,6-trichlor...