نتایج جستجو برای: soluble leptin receptor

تعداد نتایج: 677692  

2012
Michael Schaab Henriette Kausch Juergen Klammt Marcin Nowicki Ulf Anderegg Rolf Gebhardt Stefan Rose-John Juergen Scheller Joachim Thiery Juergen Kratzsch

BACKGROUND The adipokine leptin realizes signal transduction via four different membrane-anchored leptin receptor (Ob-R) isoforms in humans. However, the amount of functionally active Ob-R is affected by constitutive shedding of the extracellular domain via a so far unknown mechanism. The product of the cleavage process the so-called soluble leptin receptor (sOb-R) is the main binding protein f...

2018
Tomoaki Morioka Masanori Emoto Yuko Yamazaki Masafumi Kurajoh Koka Motoyama Katsuhito Mori Shinya Fukumoto Atsushi Shioi Tetsuo Shoji Masaaki Inaba

AIMS/INTRODUCTION A soluble form of the leptin receptor (soluble Ob-R) in the circulation regulates leptin's bioactivity, and is inversely associated with body adiposity and circulating leptin levels. However, no study has examined the clinical impact of soluble Ob-R on glucose metabolism in diabetes. The present study aimed to investigate the association of plasma soluble Ob-R levels with insu...

2015
Masafumi Kurajoh Hidenori Koyama Manabu Kadoya Mariko Naka Akio Miyoshi Akinori Kanzaki Miki Kakutani-Hatayama Hirokazu Okazaki Takuhito Shoji Yuji Moriwaki Tetsuya Yamamoto Masanori Emoto Masaaki Inaba Mitsuyoshi Namba

BACKGROUND It has been shown that visceral fat accumulation is associated with autonomic dysfunction, though the precise mechanism remains unclear. A recent basic study found that leptin can directly modulate autonomic function through the dorsomedial hypothalamus in relation to obesity. Here, we investigated the mutual relationships among plasma leptin, visceral fat accumulation, and cardiac a...

Journal: :Turkish journal of medical sciences 2014
Uzay Görmüş Özlem Tımırcı Kahraman Bahar Toptaş Turgay İsbır Çavlan Çıftçı Hasan Hakan Berkkan Altay Burak Dalan Mutia Canan Karatay

BACKGROUND/AIM Leptin is a hormone that is known to be related to weight gain and obesity. The soluble leptin receptor has been found in plasma as an important determinant of leptin sensitivity. In this study, our goal was to investigate the association between leptin levels and leptin receptor polymorphisms in a Turkish population. MATERIALS AND METHODS The sample pool of this study consiste...

Journal: :The Journal of infectious diseases 1999
F Arnalich J López R Codoceo M Jim nez R Madero C Montiel

Leptin production is increased in rodents by administration of endotoxin or cytokines. To investigate whether circulating leptin is related to cytokine release and survival in human sepsis, plasma concentrations of leptin, interleukin (IL)-6, IL-1beta, tumor necrosis factor (TNF)-alpha, soluble TNF receptor type I, IL-1 receptor antagonist (IL-1ra), and the inflammatory modulator IL-10 were mea...

M. Roostaei-Ali Mehr, R. Motamedi-Mojdehi R. Rajabi-Toustani

Leptin is secreted mainly by fat, which is involved in energy metabolism and reproduction. Leptin and itsreceptor (Ob-R) have been detected in human spermatozoa and testis, thus it can be concluded leptin involves in male physiology. The goal of this study was determination of the presence of leptin receptor mRNA in the ram testis, epididymis and spermatozoa by reverse transcription polymerase ...

Journal: :The Journal of Clinical Endocrinology & Metabolism 2003

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید