Myostatin is a secreted protein that acts as a potent inhibitor of skeletal muscle growth. Inactivation of myostatin increases muscle mass and decreases insulin resistance. The aim of this study was to determine if the improvement in insulin resistance after resistance training is associated with a decline in serum levels of myostatin. A sample of 19 obese-overweight women (age= 23.2±3.4 yr, bo...

Myostatin is a potent inhibitor of myogenesis; thus differential expression might be expected across individuals varying in responsiveness to myogenic stimuli. We hypothesized that myostatin would be differentially regulated across humans with markedly different hypertrophic responses to resistance training (RT; 16 wk). Targets were assessed in muscle biopsies at baseline (T1) and 24 h after th...

BACKGROUND Regular physical activities have a positive effect on the muscular skeletal system but overstrenuous exercise may be different. Transiently suppressed bone formation and increased bone resorption after participation in a 246-km ultradistance race has been demonstrated. PURPOSE The aim of this study was to analyze effects of the Spartathlon race on novel musculoskeletal markers. M...

To investigate the feasibility of developing a method for detection of gene doping in power-athletes, we devised an experimental model system. Myostatin is a potent negative regulator of skeletal muscle development and growth, and myostatin-knockout mice exhibit a double-muscle phenotype. To achieve knockdown, we constructed plasmids expressing short hairpin interfering RNAs (shRNAs) against my...

Myostatin is a member of the transformating growth factor-beta (TGF-beta) superfamily of proteins and is produced almost exclusively in skeletal muscle tissue, where it is secreted and circulates as a serum protein. Myostatin acts as a negative regulator of muscle mass through the canonical SMAD2/3/4 signaling pathway. Naturally occurring myostatin mutants exhibit a 'double muscling' phenotype ...

The purpose of present study was to determine the effect of 8 weeks of  resistance training on serumic myostatin, and Fibroblast Growth Factor-2 (FGF-2) level in male Wistar rats. 20 adult male wistar rats(150-250gr) were randomly divided into 2 groups [control group; n=10 (C), resistance training; n=10 (R)]. Resistance training was conducted for 8 weeks (5 session/week) on a special 1 meter he...

Patients with coronary heart disease or acute myocardial infarction after cardiac catheterization with stenting referred for phase II cardiac rehabilitation (CR) were grouped according to their preference. Cardio-pulmonary exercise testing (CPET) was used to determine oxygen uptake ((Equation is included in full-text article.)) at peak exercise and anaerobic threshold (AT). The control patients...

Duchenne muscular dystrophy (DMD) is a lethal, X-linked recessive disease affecting 1 in 3,500 newborn boys for which there is no effective treatment or cure. One novel strategy that has therapeutic potential for DMD is inhibition of myostatin, a negative regulator of skeletal muscle mass that may also promote fibrosis. Therefore, our goal in this study was to evaluate systemic myostatin inhibi...

the aim of the present study was to examine the effect of 8 weeks of resistance training and hmb supplementation on serum myostatin levels of non-athlete men. in this quasi-experimental study, 20 non-athlete men voluntarily participated in the study and were divided into experimental group (n=10, mean age 28.75±1.39 yr, height 179.83±4.30 cm, weight 81±5.27 kg and bf% 28.65±6.40) and control gr...

Sarcopenia is the loss of muscle size and function during ageing. The aim of this study was to test whether serum concentrations of myostatin and interacting proteins (GASP-1, FLRG, and follistatin) differed between young and elderly sarcopenic men. Isometric knee extensor maximal voluntary contraction and quadriceps cross-sectional area (magnetic resonance imaging measurement) were significant...