Abstract Introduction Iloperidone, a dopamine D2 receptor and serotonin 5HT2A antagonist, was evaluated for the treatment of acute manic mixed episodes associated with bipolar I disorder in adults phase 3 clinical trial. A core symptom is disturbance sleep. During this commonly presents as reduced need sleep studies finding that 69%–99% individuals report lessened or difficulties falling and/or...

Research into how protein restriction improves organismal health and lengthens lifespan has largely focused on cell-autonomous processes. In certain instances, however, nutrient effects on lifespan are independent of consumption, leading us to test the hypothesis that central, cell non-autonomous processes are important protein restriction regulators. We characterized a transient feeding prefer...

A 67-year-old woman with Alzheimer’s disease was administered 5 mg/day donepezil for approximately three years. The patient exhibited acute confusion, global impairment of cognition with disorientation, sleep disturbance, psychomotor agitation, hallucinations and delusions due to delirium at night. She was then administered 8 mg/day blonanserin for approximately one month in addition to donepez...

Selective serotonin uptake inhibitors (SSRIs) are known to stimulate the production of new neurons in the hippocampus (HPC) by increasing synaptic concentration of serotonin (5-HT). The delay in the appearance of antidepressant effects corresponds to the time required to generate new neurons. However, it is not clear which of the many serotonergic receptors in the HPC are responsible for the en...

Serotonin syndrome (SS) is an adverse drug reaction induced by hyperstimulation of postsynaptic serotonin receptors (Boyer & Shannon 2005). The syndrome includes psychiatric symptoms (unrest, disturbed sleep, elevated mood, confusion, semicoma or coma, ...), neurological symptoms (myoclonus, tremors, hyperreflexia, impaired coordination, ...), and autonomic symptoms (fever, hyperhidrosis, diarr...

The effects of oleamide, an amidated lipid isolated from the cerebrospinal fluid of sleep-deprived cats, on serotonin receptor-mediated responses were investigated in cultured mammalian cells. In rat P11 cells, which endogenously express the 5-hydroxytryptamine2A (5HT2A) receptor, oleamide significantly potentiated 5HT-induced phosphoinositide hydrolysis. In HeLa cells expressing the 5HT7 recep...

JNJ-40411813/ADX71149 (1-butyl-3-chloro-4-(4-phenylpiperidin-1-yl) pyridin-2(1H)-one) is a positive allosteric modulator (PAM) of the mGlu2 receptor, which also displays 5-Hydroxytryptamine (5HT2A) antagonism after administration in rodents due to a rodent-specific metabolite. JNJ-40411813 was compared with the orthosteric mGlu2/3 agonist LY404039 (4-amino-2-thiabicyclo [3.1.0] hexane-4,6-dicar...

Serotoninergic fibers densely innervate olfactory bulb glomeruli, the first sites of synaptic integration in the olfactory system. Acting through 5HT2A receptors, serotonin (5HT) directly excites external tufted cells (ETCs), key excitatory glomerular neurons, and depolarizes some mitral cells (MCs), the olfactory bulb's main output neurons. We further investigated 5HT action on MCs and determi...