نتایج جستجو برای: sequential experimentaldesign
تعداد نتایج: 86577 فیلتر نتایج به سال:
Purpose: Glioblastoma multiforme (GBM) is a poorly treated human brain cancer with few established clinically useful molecular prognostic markers. We characterized glioblastoma stem–like cells (GSC) according to developmental neural lineage markers and correlated their expression with patient survival. ExperimentalDesign: Immunoblot arrayof neural lineagemarkers classifiedfive independently iso...
Purpose: The prognosis of small cell lung cancer (SCLC) is poor, and there has been very little progress in the medical treatment of SCLC in the past two decades. We investigated the potential of Janus-activated kinases (JAK) inhibitor, AZD1480, for treatment of SCLC in vitro and in vivo. ExperimentalDesign: JAK1 and JAK2were inhibited byAZD1480 or siRNAs, and the effect of inhibition of JAK ge...
Purpose: To determine the maximum-tolerated dose (MTD), dose-limiting toxicities (DLT), pharmacokinetics, and pharmacodynamics of sorafenib, bevacizumab, and low-dose oral cyclophosphamide in children and young adults with recurrent/refractory solid tumors. ExperimentalDesign: Sorafenib dosewas escalated from90 to110mg/m twice dailywithfixed doses of bevacizumab at 5 mg/kg every 3 weeks and cyc...
Purpose: Doxorubicin has shown efficacy especially in combination treatment for the treatment of multiple myeloma; however, its side effects limit its use. INNO-206 is an albumin-binding prodrug of doxorubicin, which is released from albumin under acidic conditions. Because INNO-206 has not been previously evaluated in any hematologic malignancy, we determined its anti–multiple myeloma effects....
PURPOSE Anaplastic thyroid cancer (ATC) is a rare but lethal malignancy without any effective therapy. The aim of this study is to use a high-throughput drug library screening to identify a novel therapeutic agent that targets dysregulated genes/pathways in ATC. EXPERIMENTALDESIGN We performed quantitative high-throughput screening (qHTS) in ATC cell lines using a compound library of 3,282 dr...
Purpose: To generate a comprehensive "Secretome" of proteins potentially found in the blood and derive a virtual Affymetrix array. To validate the utility of this database for the discovery of novel serum-based biomarkers using ovarian cancer transcriptomic data. ExperimentalDesign: The secretomewas constructed by aggregating the data from databases of known secreted proteins, transmembrane or ...
this study evaluates the discriminative power of sequential spectrum analysis of the short-term electrocardiogram (ecg) time series in separating normal and subjects with life threatening arrhythmias like, ventricular tachycardia/fibrillation (vt/vf). the raw ecg time series is transformed into a series of binary symbols and the binary occupancy or relative distribution of mono-sequences (i.e. ...
Background: The ability to recognize the severity of the disease in those who their survival depend entirely on admission to the intensive care unit, is very valuable clinically. This study aimed to evaluate the clinical effectiveness of modified sequential organ failure assessment (MSOFA) scale to predict mortality and length of stay in intensive care unit patients respectively. Methods: Th...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید