Ss were 40 male patients hospitalized on a psychiatric ward and defined as maladjusted and 40 male patients hospitalized on a medical-surgical ward and defined as adjusted. The medical and psychiatric groups were each composed of equal subgroups of low-competence repressers, low-competence sensitizers, high-competence repressers, and high-competence sensitizers. All Ss completed a social desira...

The putative role played by insulin sensitizers in modulating adipose tissue lipolysis in the fasting state was evaluated in obese conscious Zucker rats treated with troglitazone or beta,beta'-tetramethylhexadecanedioic acid (MEDICA 16) and compared with nontreated lean and obese animals. The rates of appearance (R(a)) of glycerol and free fatty acid (FFA), primary intra-adipose reesterificatio...

Pointsource photodynamic therapy (PSPDT) is a newly developed fiber optic method aimed at the delivery of photosensitizer, light and oxygen to a diseased site. Because of a need for developing photosensitizers with desirable properties for PSPDT, we have carried out a synthetic, photophysical and phototoxicity study on a series of PEGylated sensitizers. Chlorin and pheophorbide sensitizers were...

Quantitative structure-activity relationships (QSARs) for prediction of the reaction rate constants of phenols and phenolates with three photochemically produced oxidants, singlet oxygen, carbonate radical, and triplet excited state sensitizers/organic matter, are developed. The predictive variable is the one-electron oxidation potential (E1), which is calculated for each species using density ...

Photodynamic therapy (PDT) has proved to be a viable and interesting alternative to currently used less selective methods for palliative care of cancer and, in a limited number of cases, for curative treatment. Still, in spite of impressive progress and a few approvals for clinical applications, the great potential of PDT has not yet been fully realized because of current defi ciencies of appli...

BACKGROUND Hair dye products constitute an important source of allergen exposure, and contribute importantly to allergic contact dermatitis in consumers and hairdressers. OBJECTIVES To evaluate the presence of potent contact sensitizers in oxidative hair dye products intended for home use on the US market. METHODS Ingredient labels of 107 hair dyes from 10 major brands were examined and use...

The development of non-animal methods for skin sensitization testing is an urgent challenge. Some of the most promising in vitro approaches are based on the analysis of phenotypical and functional modifications induced by sensitizers in dendritic cell models. In this work, we evaluated, for the first time, a fetal skin-derived dendritic cell line (FSDC) as a model to discriminate between sensit...

We have designed and synthesized a new symmetrical porphyrins 3a-d and their nanoparticles based on extended π-conjugation concept. The new sensitizers were fully characterized by CHN analysis, UV-Vis., H-NMR, TEM and Mass spectroscopy. The new sensitizers and their nanoparticles were evaluated as antitumor activity against HepG2, WI-38, VERO and MCF-7 cell lines. It was found that porphyrin na...

Cyclometalated ruthenium sensitizers have been synthesized that differ with number of thiophene units on the auxiliary ligands. Sensitizers possessing four (SA25, SA246, and SA285) or none (SA282) sulfur atoms in their structures, were tested in solar cell devices employing I3-/I- redox mediator, enabling an estimation of the influence of sulfur-iodine/iodide interactions on dye-sensitized sola...