نتایج جستجو برای: s pde
تعداد نتایج: 718926 فیلتر نتایج به سال:
background: the increasing use of nuclear radiation for human welfare necessitates the search for new, safe, cost effective radio protectors not only for the personnel’s charged with the responsibility of working or testing with radiations in laboratories, but also for general public. with this view the present study has been undertaken to determine the deleterious effects of sub lethal gamma r...
A phosphodiesterase (PDE) III inhibitor, amrinone, inhibited both the negative inotropic actions of verapamil and nicardipine in guinea pig ventricular papillary muscle; this effect was canceled by the protein kinase A inhibitor H-89. The PDE IV inhibitor 1,3-di-n-butyl-7-(2'-oxopropyl)xanthine (denbufylline), which elicited a negative inotropic action by itself, attenuated the action of verapa...
The goal of this study was to determine the extent to which the effects of milrinone were desensitized in heart failure (HF) and to determine the mechanisms, i.e., whether these effects could be ascribed to changes in cAMP or phosphodiesterase (PDE) activity in HF. Accordingly, we examined the effects of milrinone in seven conscious dogs before and after HF was induced by rapid ventricular paci...
Pulmonary arterial hypertension (PAH) is one of the leading causes of morbidity and mortality in adult patients with sickle cell disease (SCD). Here, we developed a model to study the early stage of PAH in SCD. We exposed wild-type and transgenic sickle cell SAD (Hbb(s)/Hbb(s)) mice to hypoxia (8% O(2)) for 7 days. Prolonged hypoxia in SAD mice only induced 1) increased neutrophil count in both...
This note is devoted to stabilizing a coupled PDE–ODE system with interaction at the interface. First, a state feedback boundary controller is designed, and the system is transformed into an exponentially stable PDE–ODE cascadewith an invertible integral transformation,where PDE backstepping is employed. Moreover, the solution to the resulting closed-loop system is derived explicitly. Second, a...
در این پایان نامه جواب های جدید برای معادلات دیفرانسیل جزئ pde معروف،ازنوع سالیتون یا امواج منفرد بررسی شده است. با در نظر گرفتن جواب های عمومی معادله موج کلاسیک و انواع مختلفی از آن،زمینه لازم با تمرکز به خصیصه هایی از جمله خطی،غیرخطی و پاشندگی معرفی شده است. یک روش ساده و موثر برای بدست آوردن جواب های دقیق جدید موج رونده از(pde)غیرخطی، روش تعادل همگن پیشنهاد شده است. علاوه بر آن این روش برای...
A detailed characterization of the cyclic nucleotide phosphodiesterase (PDEs) from normal Drosophila melanogaster was made, including purification of the two major enzymes to near homogeneity. A third more labile phosphodiesterase also was identified in crude homogenates. The total activity per fly of one of these three enzymes, PDE-II, is strongly influenced by the dunce locus. Two independent...
آنزیم های pde، هیدرولازهایی هستند که به طور انتخابی هیدرولیز نوکلئوتیدهای camp و cgmp را کاتالیز می کنند و تا کنون ١١ خانواده و ٥٣ ایزوآنزیم از آن ها شناسایی شده است. این آنزیم ها دسترسی پیام رسانه های ثانویه به عامل های درون سلولی شان را کنترل می کنند. آنزیم های pde از لحاظ ساختار، خواص کینتیکی، مکانیسم های تنظیمی، حساسیت به مهارکننده ها و پاسخ به عامل های خاص و نیز میل ترکیبی به سوبسترا(camp ...
Purpose: The carcinogenic capacity of B[a]P/B[a]PDE is supported by epidemiologic studies. However, the molecular mechanisms responsible for B[a]P/B[a]PDE-caused lung cancer have not been well investigated. We evaluated here the role of novel target PHLPP2 in lung inflammation and carcinogenesis upon B[a]P/B[a]PDE exposure. Experimental Design: We used the Western blotting, RT-PCR, [S]methionin...
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