Building on Deci and Ryan's Self-Determination Theory and Meijman and Mulder's Effort-Recovery Model, the present study examined the nature, antecedents, and consequences of working hard (i.e., workaholism and work engagement) in a Dutch convenience sample of 1,246 employees. A confirmatory factor analysis showed that workaholism and work engagement were two largely independent concepts. Crossi...

In the ‘‘Drug Delivery and Imaging of C-sweating’’ section of the Materials and Methods the drug concentrations are listed incorrectly. The correct concentrations should be described as follows: ‘‘The same site was then re-injected within 2 min with a cocktail of 280 uM atropine, 160 uM isoproterenol and 20 mM aminophylline dissolved in lactated Ringers to make a final injection volume of 0.1 m...

The early use of fresh frozen plasma as a resuscitative agent after hemorrhagic shock has been associated with improved survival, but the mechanism of protection is unknown. Hemorrhagic shock causes endothelial cell dysfunction and we hypothesized that fresh frozen plasma would restore endothelial integrity and reduce syndecan-1 shedding after hemorrhagic shock. A prospective, observational stu...

BACKGROUND Even though crystalloids are the first choice for fluid resuscitation in hemodynamically unstable patients, their potency as plasma volume expanders in hypovolemia of different etiologies is largely unknown. The objective of the study was to investigate dose-response curves of a crystalloid in hypovolemia induced by either sepsis or hemorrhagic shock. RESULTS Rats were randomized t...

Abbreviations: Ach, acetylcholine; Cch, carbachol; mAChR, CHO, chinese hamster ovary; COPD, chronic obstructive pulmonary disease; CRC, concentration-response curve; DMEM/F12, Dulbecco’s Modified Eagle Medium nutrient mixture F-12; DMSO, dimethylsulfoxide; DR, dose ratio; FLIPR, fluorometric imaging plate reader; hERG, human ether-a-go-go-related gene; KH, Krebs’ Henseleit; KRH, Krebs’ Ringers ...

Hydroxyethylstarch (HES) 200/0.5 is associated with renal failure. Several studies have suggested that renal function is affected but the subsequent arguments leave the clinician in no man's land. A recent study in Critical Care by Simon and colleagues using a two hit animal model of shock demonstrates that the use of a higher molecular weight starch, HES 200/0.5, is associated with impaired re...

BACKGROUND Sucralfate is a gastroprotectant with no known systemic effects. The efficacy of sucralfate for prevention and treatment of stress-related mucosal diseases (SRMD) in dogs is unknown. HYPOTHESIS/OBJECTIVES To develop a canine ex vivo model of SRMD and to determine the effect of sucralfate on mucosal barrier function in this model. ANIMALS Gastric antral mucosa was collected immedi...

The non-linear nature of the superelastic phase transformation in NiTi means that conventional fatigue life theory is difficult to apply. The volume fraction of martensite/parent phase and its role in the fatigue mechanism is not understood. This paper considers the fatigue life of superelastic NiTi alloys when tested at 2Hz in Ringers solution. In agreement with other researchers [1] [2] it wa...

Rachel Gunn explores the indigenization of Hollywood genres, specifically the adaptation of the horror genre in a Canadian contest. Conflicts of nation intersect with those of gender as Gunn discusses the ways in which both John Fawcett’s Ginger Snaps (2000) and David Cronenberg’s film Dead Ringers (1988) invert the traditionally masculine horror genre by interrogating the concept of the monstr...