We present a fabrication approach for the production of micromachined biodegradable microstructures, and illustrate its application in two areas: biodegradable microneedles for transdermal drug delivery, and biodegradable ratcheting surgical ties for blood vessel surgery. We fabricated solid polymer microneedles out of polyglycolide, polylactide and their copolymer using a micromolding techniqu...

A design project was carried out which began with the study and critique of office paper attachment systems, such as paperclips and staples. A set of criteria for an ideal system of attachment was then developed. This led to the design of an improved system and the manufacture of a prototype to prove the concept behind it. The concept that was developed and pursued was a ratcheting clip. The ra...

Stainless steels with harmonic-structure design have a great balance of high strength and ductility. Therefore, it is imperative to investigate their fatigue properties for engineering applications. In the present work, harmonic-structured SUS316L stainless were fabricated by mechanical milling (MM) subsequent hot isostatic pressing (HIP) process. A series ratcheting-fatigue tests performed on ...

This paper describes the fabrication of a composite agar/PDMS device for enriching short cells in a population of motile Escherichia coli. The device incorporated ratcheting microchannels, which directed the motion of swimming cells of E. coli through the device, and three sorting junctions, which isolated successively shorter populations of bacteria. The ratcheting microchannels guided cells t...