L’esame di un passo della Vita Platone laerziana (III 2) – e luoghi paralleli riferibili alla medesima tradizione permette mettere a fuoco motivo mitico cruciale nei racconti sulla concorrenza tra essere umano divinità nel gamos con una mortale: il divieto, che nume impone al ‘rivale’ inferiore natura, congiungersi la donna reca in grembo suo seme, finché l’eroina non abbia portato termine grav...

PRIMA-1Met is the methylated PRIMA-1 (p53 reactivation and induction of massive apoptosis) and could restore tumor suppressor function of mutant p53 and induce p53 dependent apoptosis in cancer cells harboring mutant p53. However, p53 independent activity of PRIMA-1Met remains elusive. Here we reported that PRIMA-1Met attenuated colorectal cancer cell growth irrespective of p53 status. Kinase p...

Presenilin-1 (PS1) is the catalytic component of the γ-secretase complex. In this study, we explore if PS1 participates in the processing of the cholinergic acetylcholinesterase (AChE). The major AChE variant expressed in the brain is a tetramer (G(4)) bound to a proline-rich membrane anchor (PRiMA). Overexpression of the transmembrane PRiMA protein in Chinese hamster ovary cells expressing ACh...

The aim of this study was to assess the efficiency of p53 reactivation and induction of massive apoptosis (PRIMA-1(Met)) in inducing myeloma cell death, using 27 human myeloma cell lines (HMCLs) and 23 primary samples. Measuring the lethal dose (LD50) of HMCLs revealed that HMCLs displayed heterogeneous sensitivity, with an LD50 ranging from 4 μM to more than 200 μM. The sensitivity of HMCLs di...

Software is believed to be increasingly the prima donna of today's computerized era. This because world getting easier reach with digital assistance, which becoming more and trendy. Tech lagging in travel business activities. Many tourism people are now interested conducting their tour promos online quickly increase local products' marketing international market. So ensure correctness, we have ...

The transcriptional regulation of proline-rich membrane anchor (PRiMA), an anchoring protein of tetrameric globular form acetylcholinesterase (G(4) AChE), was revealed in muscle during myogenic differentiation under the influence of innervation. During myotube formation of C2C12 cells, the expression of AChE(T) protein and the enzymatic activity were dramatically increased, but the level of G(4...

Targeting p53 by the small-molecule PRIMA-1/APR-246 has shown promising preclinical activity in various cancer types. However, the mechanism of PRIMA-1–induced apoptosis is not completely understood and its effect on multiple myeloma cells is unknown. In this study, we evaluated antitumor effect of PRIMA-1 alone or its combination with current antimyeloma agents in multiple myeloma cell lines, ...

It is apparent that physics and numerics are strongly linked in every serious undertaking in computational mechanics. This is in particular pronounced when the matter of study excels through a very sophisticated, even sometimes tricky physical behavior. Such a delicate characteristic is the trademark of shell structures, which are the most often used structural components in nature and technolo...

Targeting p53 by the small-molecule PRIMA-1(Met)/APR-246 has shown promising preclinical activity in various cancer types. However, the mechanism of PRIMA-1(Met)-induced apoptosis is not completely understood and its effect on multiple myeloma cells is unknown. In this study, we evaluated antitumor effect of PRIMA-1(Met) alone or its combination with current antimyeloma agents in multiple myelo...

Reactivation of the tumor suppressor activity to mutant p53 should trigger massive apoptosis and eliminate tumors. The low molecular weight compounds PRIMA-1 and the structural analog PRIMA-1MET reactivate human mutant p53 in vitro and suppress growth of human tumor xenografts in SCID mice. However, little is known about their effect on mouse mutant p53 in mouse tumor cells. We have examined th...