Abstract Morphogenesis, the process through which genes generate form, establishes tissue-scale order as a template for constructing complex shapes of body plan. The extensive growth required to build these ordered substrates is fuelled by cell proliferation, which, naively, should destroy order. Understanding how active morphogenetic mechanisms couple cellular and mechanical processes order—ra...

BACKGROUND Participation in boys' youth lacrosse has dramatically increased in recent years. Yet, research on the incidence of youth lacrosse injuries is limited. This study describes the epidemiology of boys' youth lacrosse injuries. FINDINGS Aggregate injury and exposure data was collected from 550 boys' youth lacrosse players (aged 9-15 years) from eight leagues in four states. Injury freq...

Precise intraoperative assessment of the architecture of the biliary tree could reduce lesions to intra- or extrahepatic bile ducts. The aim of this study was to test feasibility of intraoperative three-dimensional imaging during liver resections. Isocentric C-arm fluoroscopy acquires three-dimensional images during a 190 degrees orbital rotation. The bile ducts were displayed three-dimensional...

In this article we present an algorithm to determine the intersection between rays and triangles based on the idea of the study of signs with respect to triangles. One of the advantages of this approach is its robustness due to its lack of trigonometric operations or complex divisions which might alter the result of the calculations. The algorithm is similar (or even better) in time to other ex...

The generation of order and asymmetry at the cytoplasmic level is fundamental to many basic cellular functions including mitosis, directed cell movement, and developmental processes such as axis specification. All of these events are largely dependent on the cytoskeleton, which is responsible for organizing the cytoplasm of eukaryotic cells. The problem of cytoplasmic organization is particular...

The number of nuclear divisions in meiosis is strictly limited to two. Although the precise mechanism remains unknown, this seems to be achieved by adjusting the anaphase-promoting complex/cyclosome (APC/C) activity to degrade cyclin. Here, we describe a fission yeast cuf2 mutant that enters into a third nuclear division cycle, represented by ectopic spindle assembly and abnormal chromosome seg...