Intracellular processes, including endosomal escape and intracellular release, are efficiency-determining steps in achieving successful gene delivery. It has been found that the presence of acid-labile units in polymers can facilitate endosomal escape and that the presence of reducible units in polymers can lead to intracellular release. In this study, poly(amido amine)s with both bioreducible ...

Surgical site infections cause significant postoperative morbidity and increased healthcare costs. Bioadhesives used to fill surgical voids and support wound healing are typically devoid of antibacterial activity. Here we report novel syringe-injectable bioadhesive hydrogels with inherent antibacterial properties prepared from mixing polydextran aldehyde and branched polyethylenimine. These adh...

A small interfering RNA (siRNA)-loaded polyelectrolyte constructed with branched polyethylenimine (bPEI) and copolymers, consisting of polyethylene glycol (PEG), histidine (His), and glutamic acid (Glu), was developed in order to provide a tumor acidosis-triggered delivery system with low cytotoxicity.

Self-assembly supramolecular nanoparticles (SNPs) are synthesized using polyethylenimine (PEI) crosslinked by cyclodextrins (CyDs), adamantyl doxorubicin and plasmid DNA. SNPs successfully conduct the cooperative co-delivery of chemotherapeutic anticancer drug and plasmid DNA in vitro and in vivo.

Promising material for hybrid photodynamic therapy consisting of Ce0.5Y0.35Tb0.15F3 crystalline nanoparticles and Radachlorin is reported. One possible option conjugation using polyethylenimine (PEI) tested. The energy transfer reaches 28%. It shown that conjugates CeF3—Tb3+ NPs PEI—are stable, the distance between photosensitizer molecules about 5 nm.

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UNLABELLED This report describes gene transfer in vitro as well as in vivo using cetylated low-molecular mass (600 Da) polyethylenimine (28% of amine groups substituted with cetyl moieties), termed CT-PEI. This compound is hydrophobic and has to be incorporated into liposomes in order to be suitable for gene transfer studies. Serum-induced plasmid DNA degradation assay demonstrated that CT-PEI-...

Correspondence: Viara Ivanova University of Food Technologies – Plovdiv, Department of Microbiology, 26 Maritsa Blvd., 4002 Plovdiv, Bulgaria. Tel.: +359 32 603622 e-mail: [email protected] ABSTRACT Recombinant cyclodextrin glucanotransferase JCGT8-5 (CGTase, EC 2.4.1.19) was effectively immobilized by formation of chemical bounds on polyethylenimine (PEI)-activated silica particles, on silaniz...

Wastewater cleaning strategies based on the adsorption of materials are being increasingly considered, but the wide variety of organic pollutants at low concentrations still makes their removal a challenge. The hybrid material proposed here consists of a zwitterionic polyethylenimine polymer coating a magnetic core. Polyethylenimine is phosphonated at different percentages by a one-step process...