Our2007MCTarticle "Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma" (1) highlights the antitumor mechanism and response of an experimental model of anaplastic large cell lymphoma (ALCL) to an experimental agent now known as crizotinib. Anaplastic large cell lymphoma is characteriz...

FAN, AILIN. New Statistical Methods for Precision Medicine: Variable Selection for Optimal Dynamic Treatment Regimes and Subgroup Detection. (Under the direction of Dr. Wenbin Lu and Dr. Rui Song.) Due to patients’ heterogeneity and a growing number of specifically targeted treatments, precision medicine draws attentions for customization of therapies and medical decisions for individual patien...

Ovid recounts the story of Jason and his Argonauts (1), who, after dealing with jealous harpies, wandering rocks, spectral armies, and fire-snorting bulls, approach the Golden Fleece only to find it guarded by a sleepless dragon who complicates the ease with which their prize might be grasped. In the current age, we hope to revolutionize cancer therapeutics by defining drug molecules that targe...