BACKGROUND Current first-line treatments for metastatic renal cell carcinoma (mRCC) include the multityrosine kinase inhibitors pazopanib and sunitinib. Both agents had similar progression-free survival (PFS) and overall survival (OS) in the COMPARZ trial (Comparing the Efficacy, Safety and Tolerability of Pazopanib versus Sunitinib); however, the adverse event profiles of the 2 agents are diff...

A cytogenetic study was carried out on the chromosomes and the nuclear DNA content of the freshwater goby Economidichthys pygmaeus (Pisces, Gobiidae). The species is characterized by a 2n=46 karyotype consisting of 12 submetacentric and 11 subtelocentric chromosome pairs (NF=70). Major (45S) rDNA genes are terminal-centromeric located on the short arm of a single medium-small sized submetacentr...

Sexually dimorphic traits in many mate recognition systems have evolved in response to preexisting female biases. These biases are often quite general in form and are likely to be shared by predators, thereby imposing a cost on male trait expression. The Mexican tetra Astyanax mexicanus (Pisces: Characidae), a visual predator of swordtail fishes, exhibits the same visual preferences for male bo...

We have simulated the behavior of a rod shaped nanoscale ring-gated field-effect transistor (O-FET) using the PISCES-IIb[1] semiconductor drift-diffusion solver. The results from these simulations are used by a custom SPICE 3f5[2] kernel to simulate several simple logic gates. The usefulness of this kind of transistor is examined within the context of a self-assembling fabrication technique tha...

A two-step modeling approach is developed for single-event transients in linear circuits that uses the PISCES device simulation program to calculate transient currents in key internal transistor structures. Those currents are then applied at the circuit level using the SPICE circuit analysis program. The results explain the dependence of transients on input differential voltage, as well as the ...

The low-energy behaviour of 2 coupled nanomagnets or 2 coupled SQUIDs, interacting with their environment, can be described by the model of a “Pair or Interacting Spins Coupled to an Environmental Sea” (PISCES). These physical systems can then be used for a measurement operation in which system, apparatus and environment are all treated quantum mechanically. We design a “Bell/Coleman-Hepp” meas...

Probe measurements in the PISCES linear device indicate the presence of plasma radially far from where it is produced. We show that this is mainly caused by large-scale structures of plasma with high radial velocity. Data from the Tore Supra tokamak show striking similarities in the shape of these intermittent events as well as the fluctuation density probability distribution and frequency spec...