The skin is an ideal target tissue for vaccine delivery for a number of reasons. It is highly accessible, and most importantly, enriched in professional antigen presenting cells. Possessing strong similarities to human skin physiology and displaying a defined epidermis, the guinea pig is an appropriate model to study epidermal delivery of vaccine. However, whilst we have characterized the humor...

The uniaxial compressive responses of silicone rubber (B452 and Sil8800) and pig skin have been measured over a wide range of strain rates (0.004–4000 s ). The uniaxial tensile response of the silicone rubbers was also measured at low strain rates. The high strain rate compression tests were performed using a split-Hopkinson pressure bar made from AZM magnesium alloy. High gain semi-conductor s...

Dramatic declines in amphibian populations have been described all over the world since the 1980s. The evidence that the sensitivity to environmental threats is greater in amphibians than in mammals has been generally linked to the observation that amphibians are characterized by a rather permeable skin. Nevertheless, a numerical comparison of data of percutaneous (through the skin) passage bet...

Skin is an important barrier protecting the organism against external environmental factors. Determination of its mechanical characteristics as regards its structure has significant scientific and application value. In this work, uniaxial tensile tests were conducted to determine the basic mechanical parameters of skin with respect to its structure. The subject of the study were skin samples ta...

A 70 days old Large White Yorkshire weaned piglet of piggery unit of Instructional Livestock Farm Complex, Veterinary College and Research Institute, Orathanadu was presented with the history of severe rubbing of the skin against the sides of the pen, hair loss and weakness. The clinical lesion of alopecia, superficial skin fissures and hyperkeratosis were observed around dorsal region, flank r...

This paper describes a comparative investigation into the impact penetration characteristics of DNA-coated gold micro-particles into human and porcine skin. This work is aimed at establishing the link between the particle parameters required in delivering particles to the epidermis of pigs and humans. The particles are delivered to the skin using the PowderJect concept: a method that accelerate...

Our research group is comparing clinical, histological and molecular healing profiles of oral and skin wounds using human and pig models. The goal is to determine the molecular cues that lead to scarless healing in the oral mucosa and use that information to develop scar prevention therapies for skin and prevent aberrant wound healing in the oral cavity. Wound healing in human and pig palatal m...

Human adipose-derived mesenchymal stem cells (hADMSCs) are believed to be potential key factors for starting the regenerative process after tissue injury. However, an efficient method of delivering these regenerative cells to an external wound site is still lacking. Human amnion and pig skin have long been used as skin wound dressings for the treatment of burns and other skin lesions. Herein, w...

In recent years many efforts have been made to replace dermal toxicity testing of chemicals in the animal by in vitro assays. As a member of a German research consortium, we have previously contributed to the validation of an in vitro test protocol for percutaneous absorption studies on the basis of reconstructed human epidermis and both human and pig skin ex vivo. Aiming to assess the barrier ...

24 25 In the present study, in vitro permeation experiments in a Franz diffusion cell were performed 26 using different synthetic polymeric membranes and pig ear skin to evaluate a rivastigmine 27 (RV) transdermal drug delivery system. In vitro-in vivo correlations (IVIVC) were examined 28 to determine the best model membrane. In vitro permeation studies across different synthetic 29 membranes ...