BACKGROUND The purpose of this study was to evaluate the effects of topical nipradilol monotherapy for 5 years on intraocular pressure, visual field performance, and optic disk topography. METHODS Thirty patients with normal tension glaucoma were monitored for intraocular pressure every 1-3 months. A Humphrey visual field test and measurement of optic disk configuration using the Heidelberg r...

the objective of this research was to estimate the genetic parameters and trend of somatic cell count in holstein cows of iran using test day records. the phenotypic the used data consisted of were consisting of 407167 first lactation test day records the which were collected by the center of animal breeding and livestock production improvement center of iran during 2009 to 2013. somatic cell c...

A survey on opium use was earned out in Tinsukia district of upper Assam to assess the present prevalence and pattern of opium abuse and compared with earlier findings of the year 1981 (Baruah et al., 1995). A total of 75 addicts could be detected during the survey and 61 were interviewed using structured questionnaire. The results indicate significant decline in prevalence in opium use over th...

Persistence is a prime example of phenotypic heterogeneity, where a microbial population splits into two distinct subpopulations with different growth and survival properties as a result of reversible phenotype switching. Specifically, persister cells grow more slowly than normal cells under unstressed growth conditions, but survive longer under stress conditions such as the treatment with bact...

Despite their evolutionary significance, little is known about the adaptation dynamics of genomically rewired cells in evolution. We have confronted yeast cells carrying a rewired regulatory circuit with a severe and unforeseen challenge. The essential HIS3 gene from the histidine biosynthesis pathway was placed under the exclusive regulation of the galactose utilization system. Glucose contain...

Temperature-sensitive periods were determined by application of temperature shifts and shocks to 3 temperature-sensitive cell division arrest (cda) mutants of Tetrahymena thermophila. A restrictive temperature, 36 degrees C, was found at which all 3 mutants are fully penetrant, yet other physiological effects are minimal. At this temperature, the temperature-sensitive period of cdaC2 is a uniqu...

Natural selection is an important factor influencing variation in the human genome, but most genetic studies of natural selection have focused on variants with unknown phenotypic associations. This trend is changing. New studies are rapidly revealing the effects of natural selection on genetic variants of known or likely functional importance.

in order to study on the effect of incomplete sire's pedigree on the prediction of breeding value and estimation of genetic trend, two quantitative traits such as weaning weight and average daily gain with heritabilities 0.15 and 0.30 were simulated. phenotypic, genetic and environmental correlations were assumed 0.5. resulted data files with different proportion of missed sire pedigree (0...

Methods of ancestor reconstruction are important tools for evolutionary inference that are difficult to test empirically because ancestral states are rarely known with certainty. We evaluated reconstruction methods for continuous phenotypic characters using taxa from an experimentally generated bacteriophage phylogeny. Except for one slowly evolving character, the estimated ancestral states of ...