The link between mechanics and biology in the generation and the adaptation of bone has been studied for more than a century in the context of skeletal development and fracture healing. However, the interplay between mechanics and biology in de novo generation of bone in postnatal defects as well as healing of morcellized bone graft or massive cortical bone autografts is less well understood. T...

This scanning electron microscopic study examined the spatial and temporal features of proliferating vessels of regenerating bone tissue and blood supply during distraction osteogenesis. A rat model of tibial lengthening was used with a protocol divided into a latency period of 7 days, a distraction period that lasted 14 days with a daily distraction rate of 0.5 mm in two steps, and a consolida...

Background: We aimed to determine the expression of two neuropeptides, neuropeptide Y (NPY) and vasoactive intestine peptide (VIP), in the pathological tissues of congenital pseudarthrosis of the tibia (CPT) patients for understanding the etiology and pathogenesis of CPT. Methods: Periosteum and bone specimens from 20 CPT patients were studied, in comparison to 20 normal periosteum and bone tis...

Better understanding of bone growth and regeneration mechanisms within periosteal tissues will improve understanding of bone physiology and pathology. Macrophage contributions to bone biology and repair have been established but specific investigation of periosteal macrophages has not been undertaken. We used an immunohistochemistry approach to characterize macrophages in growing murine bone an...

INTRODUCTION The periosteum serves as a stabilizing boundary membrane to the bone it envelops and is known to contain pluripotent and osteochodroprogenitor cells. Periosteal cells have been shown to have the capacity to infill critical sized defects with proliferative woven bone within weeks of injury [1,2]. Critical sized defect healing has been shown to be maximal when cells egress from perio...

Introduction: Many pathological processes such as infections, intoxications, and malignant tumors were spread through the lymphatic vessels of thoracic cavity. In present study, we investigated anatomy lymph nodes cavity in humans.
 Materials methods: The examination was performed on 60 cadavers fetuses (25), newborn children (14), (11), adults (10). Lymphatic rib periosteum, costovertebra...

The primary hypertrophic osteoarthropathy (pachydermoperiostosis) is a hereditary disease characterized by skin thickening (pachydermia), finger clubbing, and proliferation of periosteum (periostitis) with subperiosteal new bone formation. We describe the cases of two brothers of 30 and 24 years, who consulted due to bone pain, arthralgia and oligoarthritis. Pachydermia, hyperhidrosis, seborrhe...

Fracture healing is a complex process that involves presence of osteoprogenitor cells and growth factors. Therefore, the integrity of the fracture site surrounding tissues including periosteum is necessary in order to provide the resources for bone regeneration. The purpose of this review is to organize and synthesize the relevant information regarding periosteum and fracture repair. Periosteum...

The periosteum is a thin layer of connective tissue that covers the outer surface of a bone in all places except at joints (which are protected by articular cartilage). As opposed to bone itself, it has nociceptive nerve endings, making it very sensitive to manipulation. It also provides nourishment in the form of blood supply to the bone. The periosteum is connected to the bone by strong colla...

A case of hypertrophic osteoarthropathy in association with malignant tonsil tumour is reported. It involved a patient in whom the bone disorder was detected 10 months prior to the clinical manifestation of the tumour. Hypertrophic pneumic osteoarthropathy is a clinical and radiological syndrome characterized by proliferation of periosteum in long bones with digital clubbing. In over 90 % of th...