It has been known since the studies of Neubauer in 1909 and of Knoop in 19107"' that the mammalian organism is able to degrade a-amino acids to a-keto acids. Knoop advanced the hypothesis that this degradation involved an oxidative deamination.' According to this hypothesis, the imino derivative of the amino acid is first formed in an oxidative step and, in turn, the imino compound yields the c...

Background. Because acute exercise increases systemic catecholamines, we sought to determine whether exercise training would alter daily or exercise-related catecholamine release and inactivation. Methods and Results. In 24-hour urine collections, catecholamines and metabolites provided indexes of overall oxidative deamination, sulfation, and O-methylation. Plasma catecholamines, the sulfoconju...

The growth and metabolism of the live vaccine strain of Pasteurella tularensis in different media were investigated. Maximal growth was observed in a medium containing a sulfuric acid digest of casein as amino acid source. Amino acid metabolism produced considerable ammonia, and the rate of ammonia evolution was directly proportional to the growth rate. The most likely route for amino acid brea...

A series of lipophilic 2-substituted 5,7-di-tert-butylbenzoxazoles was prepared in average yields by the reaction of 3,5-di-tert-butyl-1,2-benzoquinone with amino acids and dipeptides bearing N-terminal glycine. Dipeptides having other N-terminal amino acids undergo oxidative deamination. 5,7-Di-tert-butylbenzoxazoles have shown activity against Mycobacterium tuberculosis and some nontuberculou...

Glutamate dehydrogenases are homooligomeric enzymes that catalyse the reversible oxidative deamination of glutamate to 2-oxoglutarate, thereby linking nitrogen metabolism and the tricarboxylic acid cycle. Four different classes of the enzyme are known in microbes that differ in size and cofactor specificity. Despite some common features, the kinetic properties of the enzymes from different spec...