Background: Nucleolar organizer regions (NORs) are defined as nucleolar components containing a set of argyrophilic proteins, which are selectively stained by silver methods. After silver-staining, the NORs can be easily identified as black dots exclusively localized throughout the nucleolar area and are called AgNORs. AgNORs have been used to assess biologic aggressiveness of lesions, such as ...

Objective. Oral exfoliative cytology (OEC) has been implemented in the diagnosis of pathologic lesions for ages. The present study was undertaken to evaluate the cytomorphological features of some of the commonest potentially malignant disorders (leukoplakia, lichen planus, and oral submucous fibrosis) through a simple procedure and illustrate its importance in mass screening. Materials and Met...

Free radical induced lipid peroxidation has been implicated in pathogenesis of several pathological disorders. Lipid peroxidation products malonaldehyde (MDA) was analyzed in 25 patients of leukoplakia, 47 patients of oral submucous fibrosis, 21 patients of candidiasis, 67 patients of dental caries, 62 patients of oral cancer and 50 patients of healthy subject served as a control. Significantly...

Oral Submucous fibrosis is a chronic progressive debilitating disease and often considered to be a potentially malignant disorder. Development of epithelial dysplasia in oral sub mucous fibrosis is debatable and the role of epithelium and connective tissue bed in its initiation, progression and promotion had been studied by various authors. Changes in epithelium of oral sub mucous fibrosis are ...

BACKGROUND It is generally accepted that the development of cancer in the oral mucosa is preceded by an identifiable non-invasive precursor lesion. The aim of this follow-up study was to estimate the rate and the time to transformation in a group of patients from southern Taiwan with potentially malignant oral epithelial lesions. METHODS The follow-up time is defined as the duration between t...

oral submucous fibrosis (osmf) is a potentially malignant oral condition effectively linked to the causative habit of chewing areca nut. since its first description in the 1950s, numerous epidemiological, biochemical, histological, and genetic studies have been reported. while most studies point out to the cause and effect of areca nut, co-additive factors are also implicated in the progression...

We describe an interesting case of oral sub mucous fibrosis accompanied by severe trismus in a 23 years old man. The patient had initially been diagnosed as having internal derangement of the temporomandibular joint and conservative treatment had failed to decrease the symptoms. Despite extremely limited temporomandibular joint movement, cone beam computed tomography revealed no important abnor...

Oral submucous fibrosis is a chronic, insidious disease affecting the oral cavity and sometimes pharynx. Although occasionally preceded and/or associated with vesicle formation, is always associated with juxtaepithelial inflammatory reaction followed by fibro elastic changes in lamina propria with epithelial atrophy leading to stiffness of oral cavity leading to trismus and inability to eat. Al...