نتایج جستجو برای: one locus mismatch
تعداد نتایج: 2075455 فیلتر نتایج به سال:
The clustered regularly interspaced short palindromic repeats (CRISPR) system has been adopted for a wide range of biological applications including genome editing. In some cases, dissection of genome functions requires allele-specific genome editing, but the use of CRISPR for this purpose has not been studied in detail. In this study, using the p16INK4a gene in HCT116 as a model locus, we inve...
The aim of the present study was to investigate the relations of locus of control, rumination, and worry with depression and anxiety in a sample of depressed and anxious patients. A second purpose of the study was to examine the mediating role of rumination and worry on the relationship between locus of control with depression and anxiety. One hundred and twelve patients with major depression a...
Selection of cells for resistance to cisplatin, a well-recognized mutagen, could result in mutations in genes involved in DNA mismatch repair and thereby to resistance to DNA-alkylating agents. Parental cells of the human ovarian adenocarcinoma cell line 2008 expressed liMI.HI when analyzed with immunoblot. One subline selected for resistance to cisplatin (2008/A) expressed no hMLHl, whereas an...
Defective DNA mismatch repair in human tumors leads to genome-wide instability of microsatellite repeats and a molecular phenotype referred to as microsatellite instability (MSI). MSI has been reported in a variety of cancers and is a consistent feature of tumors from patients with hereditary non-polyposis colorectal cancer. Approximately 20% of cancers of the uterine endometrium, the fifth mos...
Attitudes have an important role in various behaviors. This study investigated the role of locus of control as a mediator over the social creativity of children according to their creativity attitudes. One hundred five male and female elementary students in Shiraz city participated in the study. Children’s social creativity assessed by Mouchiroud& Lubart. Also Students completed Nowicki – Stric...
Mismatch between bone marrow transplant (BMT) patient and donor for an amino acid polymorphism within the adhesion molecule CD31 has recently been reported to increase risk for the development of graft-versus-host disease (GVHD). We further examined this association in a larger series of 301 BMT patients (227 with grade III/IV GVHD and 74 with grade 0 GVHD) and their HLA-identical sibling donor...
We hypothesized that the compatibility of each HLA loci between donor and patient induced divergent transplant-related immunologic responses, which attributed to the individualized manifestation of clinical outcomes. Here, we analyzed 7898 Japanese pairs transplanted with T-cell-replete marrow from an unrelated donor with complete HLA allele typing data. Multivariable competing risk regression ...
To improve the clinical outcome of allogeneic hematopoietic stem cell transplantation from an unrelated donor, the identification of human leukocyte antigen (HLA) alleles responsible for immunologic events such as graft-versus-host disease (GVHD), engraftment failure, and graft-versus-leukemia effect is essential. Genomic typing of HLA-A, -B, -C, -DRB1, and -DQB1 was retrospectively performed i...
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