نتایج جستجو برای: oncogenicity
تعداد نتایج: 613 فیلتر نتایج به سال:
DEPARTMENT OF PESTICIDE REGULATION MEDICAL TOXICOLOGY BRANCH SUMMARY OF TOXICOLOGY DATA Trifloxystrobin Chemical Code # 5321, Tolerance # 52415 SB 950 # NA Original: 5/17/00 Revised: 6/26/01 I. DATA GAP STATUS Chronic toxicity, rat: No data gap, no adverse effect Chronic toxicity, dog: No data gap, no adverse effect Oncogenicity, rat: No data gap, no adverse effect Oncogenicity, mouse: No data ...
In a preeeding paper, we demonstrated the oncogenicity of the infectious canine hepatitis (ICH) virus in newborn hamsters (KINJo et al., 1968). Although neither the primary tumors induced in hamsters by the ICH virus or the transplanted tumors contained dernonstrable infectious virus, they did, however contain an ICH virus specific tumor antigen. Also the tumor-bearing animals developed complem...
Secretory clusterin (sCLU) is associated with hepatocellular carcinoma (HCC) progression by contributing to angiogenesis, chemoresistance, cell survival, and metastasis. However, the sCLU expression at early stage of HCC progression remains to be clarified. In this study, the alteration of sCLU oncogenicity was firstly evaluated in HCC- and their para-cancerous- tissues. The incidence of sCLU e...
DEPARTMENT OF PESTICIDE REGULATION MEDICAL TOXICOLOGY BRANCH SUMMARY OF TOXICOLOGY DATA Fipronil Chemical Code # 3995, Tolerance # 52062 SB 950 # NA Original: April 26, 2005 Revised: December 12, 2006, July 16, 2010, 12/20/10, 3/25/11 I. DATA GAP STATUS Chronic toxicity, rat: No data gap, possible adverse effect indicated Chronic toxicity, dog: No data gap, possible adverse effect indicated Onc...
Members of the RAS small GTPase family regulate cellular responses to extracellular stimuli by mediating the flux through downstream signal transduction cascades. RAS activity is strongly dependent on its subcellular localization and its nucleotide-binding status, both of which are modulated by posttranslational modification. We have determined that RAS is posttranslationally acetylated on lysi...
Human T-cell leukemia virus-1 (HTLV-1) is the first pathogenic human retrovirus identified in 1979 by the Gallo group. HTLV-1 causes fatal T-cell leukemia (adult T cell leukemia) and a progressive myelopahy (HTLV-1-associated myelopathy/ tropical spastic paraparesis, HAM/TSP) and other disorders. Since the discovery of HTLV-1, several other microorganisms are demonstrated to cause cancer in hum...
SOX9 [sex-determining region Y (SRY)-box 9 protein], a high mobility group box transcription factor, plays critical roles during embryogenesis and its activity is required for development, differentiation, and lineage commitment in various tissues including the intestinal epithelium. Here, we present functional and clinical data of a broadly important role for SOX9 in tumorigenesis. SOX9 was ov...
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