Background: The maintenance, regulation, and dynamics of heterochromatin in the human malaria parasite, Plasmodium falciparum, has drawn increasing attention due to its regulatory role mutually exclusive virulence gene expression silencing key developmental regulators. The advent genome-wide analyses such as chromatin-immunoprecipitation foll...

Background: Tuberculosis (TB) is among the deadliest diseases and a significant cause of illness across globe. Several studies on mycobacterial proteins, such as proteases transporters that are essential for survival pathogenesis have aimed to develop an efficient anti-tubercular agent. In mycobacterium, lysine exporter (LysE) amino acid transporter probable target a...

Background: Bovine congestive heart failure (BCHF) has become increasingly prevalent among feedlot cattle in the Western Great Plains of North America with up to 7% mortality affected herds. BCHF is an untreatable complex condition involving pulmonary hypertension that culminates right ventricular and death. Genes associated have not been previously identified. Our a...

Background: The SARS-CoV-2 pandemic is a global threat to humans and the world’s economy. Effective safe vaccines against this virus are essential control eradicate pandemic. currently applied carry spike-protein mRNA/cDNA. These go through several cellular processes in recipients for producing antigens. On contrary, RBD (receptor binding domain)-protein an antigen. ...

The Psilocybe genus is well known for the synthesis of valuable psychoactive compounds such as Psilocybin, Psilocin, Baeocystin and Aeruginascin. The ubiquity Psilocybin in has been attributed to a horizontal gene transfer mechanism ~20Kb cassette. A recently published highly contiguous reference genome derived from long read single molecule sequencing underscored interesting variation t...

background bovine viral diarrhea (bvd) is an economically important disease of cattle with a worldwide distribution. diagnosis of bvd relies on laboratory-based detections of its viral causing agent or virus specific antibodies. the most common laboratory method used for this purpose is the elisa. bovine viral diarrhea virus (bvdv) nonstructural protein 3 (ns3) is one of the most highly conserv...

The hepatitis C virus (HCV) NS3 protease cleaves the viral polyprotein at specific sites to release the putative components of the HCV replication machinery. Selective inhibition of this enzyme is predicted to block virus replication, and NS3 is thus considered an attractive candidate for development of anti-HCV therapeutics. To set up a system for analysis of NS3 protease activity in cultured ...

Background: Molecular breeding is an essential tool for accelerating genetic gain in crop improvement, towards meeting the need to feed ever-growing world population. Establishing low-cost, flexible genotyping platforms small, public and regional laboratories can stimulate application of molecular developing countries. These serve plant projects requiring low- medium...

BACKGROUND Hepatitis C virus (HCV) is able to down-regulate innate immune response. It is important to know the immune pathways that this virus interacts with. HCV non-structural protein 3 (NS3) plays an important role in this viral feature. HCV NS3 protein could affect the expression of antiviral protein such as viperin, and interleukin 28whichare important proteins in antiviral response. OB...

BACKGROUND Hepatitis viruses are one of the most important concerns in the patients on hemodialysis who are at high risk for blood-borne infections. GB virus C (GBV-C)/hepatitis G virus (HGV) is positive-stranded RNA virus with global distribution, which codes structural and nonstructural proteins (such as NS3). OBJECTIVES Review on literature about Iranian HGV isolates showed that there was ...