The effect of combinations of a mammalian target of rapamycin (mTOR) inhibitor, temsirolimus, and an estrogen receptor-alpha (ERalpha) antagonist, ERA-923, on breast carcinoma in culture and in a xenograft model has been studied. Phase III trials are underway using temsirolimus for several cancers. ERA-923 was studied in a phase I trial for tamoxifen refractory metastatic breast cancer and was ...

*Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, and Department of Medicine, Harvard Medical School, Boston, MA 02215; †Gustaf A. Carlson School of Chemistry and Biochemistry, Clark University, 950 Main Street, Worcester, MA 01610; ‡Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139; and §Department of Neurology, David Geffen Sch...

Sward composition and structure influence herbage intake of grazing animals. We conducted a grazing study to examine how forage mixture complexity affected sward structure. Replicated 1-ha pastures (Hagerstown silt loam soil: fine, mixed, semiactive, mesic, Typic Hapludalf) were planted to either orchardgrass (Dactylis glomerata L.) and white clover (Trifolium repens L.) or a nine-species mixtu...

Six songbird species were studied to determine how testis size varies in relation to latitude, using data from breeding areas at latitudes 7°N to 69°N. Three of the species (Carpodacus mexicanus, Vireo olivaceus, Geothylpis trichas) exhibited a significant positive relationship, one (Passerculus sandwichensis) a significant negative relationship, and two (Agelaius phoeniceus, Spizella passerina...

Compound 1 [(E)-4-fluoro-N-(6-((4-(2-hydroxypropan-2-yl)piperidin1-yl)methyl)-1-((1S,4S)-4-(isopropylcarbamoyl)cyclohexyl)-1Hbenzo[d]imidazol-2(3H)-ylidene)benzamide], a new, potent, selective anaplastic lymphoma kinase (ALK) inhibitor with potential application for the treatment of cancer, was selected as candidate to advance into efficacy studies in mice. However, the compound underwent mouse...