review of eggshell pigmentation. Worlds Poult. Sci. J. 43, 238–246. 17. Collias, E.C. (1993). Inheritance of eggcolor polymorphism in the village weaver (Ploceus-Cucullatus). Auk 110, 683–692. 18. Hutt, F.B. (1949). Genetics of the Fowl (New York: McGraw-Hill). 19. Miksik, I., Holan, V., and Deyl, Z. (1996). Avian eggshell pigments and their variability. Comp. Biochem. Physiol. BBioche. Mol. Bi...

Clark Graduate School of Geography, Clark University, Worcester, 01610, USA; Département de Géographie, Université de Montréal, Montréal, USA; Department of Natural Resource Sciences and McGill School of Environment, McGill University, Sainte-Anne-de-Bellevue, Canada; Geography and Urban Studies Department, Temple University, Philadelphia, 19122, USA; Department of International Development, Co...

Summer CO2 evasion from streams and rivers in the Kolyma River basin, north-east Siberia Blaize A. Denfeld, Karen E. Frey, William V. Sobczak, Paul J. Mann & Robert M. Holmes 1 Graduate School of Geography, Clark University, 950 Main St. Worcester, MA 01610, USA 2 Department of Biology, College of the Holy Cross, 1 College Street, Worcester, MA 01610, USA 3 Woods Hole Research Center, 149 Woods...

1Elements Strategy Initiative Center for Magnetic Materials, National Institute for Materials Science, Tsukuba 305-0047, Japan 2Computational Materials Science Center, National Institute for Materials Science, Tsukuba 305-0047, Japan 3Research Center for Strategic Materials, National Institute for Materials Science, Tsukuba 305-0047, Japan 4School of Physics, University of Sydney, Sydney 2006, ...

In mammals, identifying the contribution of specific neurons or networks to behavior is a key challenge. Here we describe an approach that facilitates this process by enabling the rapid modulation of synaptic inhibition in defined cell populations. Binding of zolpidem, a systemically active allosteric modulator that enhances the function of the GABAA receptor, requires a phenylalanine residue (...

The subarachnoid space, where cerebrospinal fluid (CSF) flows over the brain and spinal cord, is lined on one side by arachnoid barrier (AB) cells that form part of the blood-CSF barrier. However, despite the fact that drugs are administered into the CSF and CSF drug concentrations are used as a surrogate for brain drug concentration following systemic drug administration, the tightjunctioned A...

We describe the creation of monodisperse microbeads of polydimethylsiloxane (PDMS) via a microfluidic approach. Using a flow-focusing configuration, a PDMS precursor solution is dispersed into microdroplets within an aqueous continuous phase. These droplets are collected and thermally cured off-chip into solid microbeads. Our microfluidic technique allows for direct integration of payloads into...

PURPOSE Tamoxifen is an antiestrogen used in women who have estrogen receptor (ER)-alpha-positive breast cancer. Unfortunately, resistance to tamoxifen is common in women with metastatic disease and side effects, including increased risk of endometrial cancer, exist. Here we describe the activity of a new selective ER modulator, ERA-923, in preclinical models focused on these limitations. EXP...

Variation in summer nitrogen and phosphorus uptake among Siberian headwater streams John D. Schade, Erin C. Seybold, Travis Drake, Seth Spawn, William V. Sobczak, Karen E. Frey, Robert M. Holmes & Nikita Zimov 1 Environmental Studies Department, St. Olaf College, 1520 St. Olaf Avenue, Northfield, MN 55057, USA 2 Nicholas School of the Environment, Duke University, PO Box 90328, Durham, NC 27708...