The potential toxic effects of nitrate-nitrite-nitrosamine on pancreatic β cell have remained a controversial issue over the past two decades. In this study, we reviewed epidemiological studies investigated the associations between nitrate-nitrite-nitrosamines exposure, from both diet and drinking water to ascertain whether these compounds may contribute to development of type 1 diabetes. To id...

N-nitrosamines are a class of carcinogenic chemical compound. Considering the large-scale application agrochemicals globally, elimination from pesticides should be priority for manufacturers and regulators. A set methods was developed validated determination toxicologically relevant N-nitrosamine impurity ethalfluralin (ethyl-N-(2-methylallyl) N-nitroso amine—EMANA) in 33% w v−1 emulsifiable co...

Throughout human history, plant products have been used for many purposes including as medicines. Herbal products and spices can be used as preventive agents against cancer due to their antimicrobial, antioxidant and antitumorigenic properties. This study was designed to evaluate the potential protective effect of curcum in rats administered nitrosamine precursors; dibutylamine (DBA) and sodium...

In an amine-based CO2 capture from a coal-fired power plant, nitrosamines can be generated as a result of the reaction between impurities such as NOx (an example of a nitrosating agent) in the flue gas with amine solutions in the absorption column. There is the potential that the nitrosamines can be emitted to the atmosphere if adequate control measures are not put in place. As is well known, a...

Previous studies have shown that a diet high in fat and marginally deficient in lipotropes enhances aflatoxin B] hepatocarcinogenesis and depresses hepatic drug metabolism in rats. In this study we have compared induction of tumors by jV-nitrosodimethylamine, ./V-nitrosodiethylamine, or jV-nitrosodibutylamine in normal or marginally lipotrope-deficient rats fed a high-fat diet. The deficiency s...

The effect of a delay in starting 13-cis-retinoic acid treatment on the inhibition of urinary bladder carcinoma induced by N-butyl-N-(4-hydroxybutyl)nitrosamine was studied in male Fischer 344 rats. Animals received a total p.o. dose of either 1200, 1800 or 2400 mg N-butyl-N-(4-hydroxybutyl)nitrosamine over a period of six weeks. At either one, five, and nine weeks after the last N-butyl-N-(4-h...

An analytical method was developed for the determination of the extraction of volatile N-nitrosamine compounds including N-nitrosodimethylamine ( NDMA) , N-nitrosodiethylamine (NDEA), N-nitrosodipropylamine (NDPA), N-nitrosodibutylamine (NDBA), N-nitrosopiperidine (NPIP), and N-nitrosopyrrolidine (NPYR) from salted aquatic products by gas chromatography-mass spectrometry (GC-MS). In this experi...

Using a method for nitrosamine analysis that gives high recovery values and that is free from artifactual synthesis of nitrosamines, we have shown that human feces do not contain volatile nitrosamines (detection limit, 0.1 to 0.5 /ng/kg). We also showed that nitrosation reactions are not catalyzed by fecal organisms. Following a 2-day anaerobic incubation of feces with either a secondary aminé...