background: cyclosporine a (csa) is an immunosuppressant with therapeutic indications in various immunological diseases; however, its use is associated with chronic nephropathy. oxidative stress has a crucial role in csa-induced nephrotoxicity. the present study evaluates the protective effect of edaravone on csa-induced chronic nephropathy and investigates its antioxidant and nitric oxide modu...

indirect evidence suggests that estrogen is involved in the etiology of breast cancer. estrogen is also thought to modulate nitric oxide (no) in human breast tumor tissue via regulation of inducible nitric oxide synthase (inos). objectives of this study were to determine whether estradiol (e2) affects inos expression level in breast cancer cells and to study the effect of various concentrations...

Dragon fruit is a prebiotic source of oligosaccharides. This the first report on study that evaluates anti-inflammatory effects dragon oligosaccharides (DFO) macrophage cell line. experiment evaluated DFO both gene and protein expression levels in inflammatory response lipopolysaccharide-induced RAW 264.7 The results showed significantly inhibited prostaglandin-E2, nitric oxide, tumor necrosis ...

BACKGROUND Recent studies in both humans and animal models strongly suggest the contribution of the host immune response to Helicobacter pylori-related disease. Inducible nitric oxide synthase has been shown to be up-regulated in the gastric epithelium during H. pylori gastritis, suggesting a role in inflammation. MATERIALS AND METHODS C57BL/6 wild-type and inducible nitric oxide synthase gen...

Inducible nitric oxide synthase (iNOS) gene expresses a calcium calmudolin-independent enzyme which can catalyse NO production from L-arginine. The induction of iNOS activity has been demonstrated in a wide variety of cell types under stimulation with cytokines and lipopoly saccharide (LPS). Previous studies indicated that all nitric oxide synthases (NOS) activated in human umbilical vein endot...

inducible nitric oxide synthase (inos) gene expresses a calcium calmudolin-independent enzyme which can catalyse no production from l-arginine. the induction of inos activity has been demonstrated in a wide variety of cell types under stimulation with cytokines and lipopoly saccharide (lps). previous studies indicated that all nitric oxide synthases (nos) activated in human umbilical vein endot...

OBJECTIVE Nitric oxide is produced by endothelial nitric oxide synthase, and its production can be influenced by polymorphisms of the endothelial nitric oxide synthase gene. Because candidate genes responsible for susceptibility to ankylosing spondylitis are mostly unknown and available data suggest that there may be problems related to the nitric oxide pathway, such as endothelial dysfunction ...

Background: Cyclosporine A (CsA) is an immunosuppressant with therapeutic indications in various immunological diseases; however, its use is associated with chronic nephropathy. Oxidative stress has a crucial role in CsA-induced nephrotoxicity. The present study evaluates the protective effect of edaravone on CsA-induced chronic nephropathy and investigates its antioxidant and nitric oxide modu...

MRL-lpr/lpr mice spontaneously develop various manifestations of autoimmunity including an inflammatory arthropathy and immune complex glomerulonephritis. This study examines the role of nitric oxide, a molecule with proinflammatory actions, in the pathogenesis of MRL-lpr/lpr autoimmune disease. MRL-lpr/lpr mice excreted more urinary nitrite/nitrate (an in vivo marker of nitric oxide production...

Migraine shows strong familial aggregation. However, the number of genes involved in the disorder is unknown and not identified. Nitric oxide is involved in the central processing of pain stimuli and plays an important role in the regulation of basal or stimulated vasodilation. Nitric oxide synthase, which controls the synthesis of nitric oxide, could possibly be a cause, or candidate gene, in ...