Sciatica in patients with disk disease was long ascribed to pressure put on the sciatic nerve root by a herniated disk. However, a role for chemical factors acting in conjunction with this mechanical insult is suggested by a number of clinical observations: disk surgery does not consistently provide pain relief, large disk herniations are not always symptomatic, severe pain may be present in pa...

The implantation of any foreign material into the body leads to development an inflammatory and fibrotic process—the reaction (FBR). Upon a tissue, cells immune system become attracted attempt degrade it. If this degradation fails, fibroblasts envelop form physical barrier isolate it from rest body. Long-term medical devices faces great challenge presented by FBR, as cellular response disrupts ...

Limbal stem cell (LSC) deficiency is a frequent and severe complication after chemical injury to the eye. Previous studies have assumed this mediated directly by caustic agent. Here we show that LSC damage occurs through immune mediators, even without direct LSCs. In particular, pH elevation in anterior chamber (AC) causes acute uveal stress, release of inflammatory cytokines at basal limbal ti...

Afferent A- and C-fibers regenerating into a nerve following peripheral nerve injury are exposed to inflammatory mediators released by Schwann cells, resident and invading macrophages, and other inflammatory cells. Here we tested the hypothesis that ongoing and evoked activity in these afferent fibers are enhanced by a mixture of inflammatory mediators [inflammatory soup (IS)] applied to the in...

Previously, we proposed the hypothesis that similarities in inflammatory response observed acne vulgaris and degenerative disc disease (DDD), especially central role of interleukin (IL)-1?, may be further evidence anaerobic bacterium Cutibacterium (previously Propionibacterium) acnes underlying aetiology degeneration. To investigate this, examined upregulation IL-1?, other known IL-1?-induced m...

Acknowledgements: The authors are grateful to Dr. Peter Reeh for comments and critical review of this manuscript. ABSTRACT Afferent A-and C-fibers regenerating into a nerve following peripheral nerve injury are exposed to inflammatory mediators released by Schwann cells, resident and invading macrophages and other inflammatory cells. Here we tested the hypothesis that ongoing and evoked activit...

Tissue injury and inflammation result in release of various mediators that promote ongoing pain or pain hypersensitivity against mechanical, thermal and chemical stimuli. Pro-nociceptive mediators activate primary afferent neurons directly or indirectly to enhance nociceptive signal transmission to the central nervous system. Excitation of primary afferents by peripherally originating mediators...

abstract introduction: interferential current is one of the most popular kinds of electrical stimulation that are used in electrotherapy. despite its clinical popularity, there have been limited studies to investigate how this stimulation protocol affects the nerve fibers. this study was aimed to develop a realistic model for the stimulation of nerve fibers by interferential currents and using ...

BACKGROUND Peripheral nerve repair is often complicated by fibroblastic scar formation, nerve dysfunction, and traumatic neuroma formation. Use of silicone may improve outcomes of these repairs. In this study, we tried to evaluate effectiveness of silicone gel on rats’ sciatic nerve repair, axon regeneration and scar formation around and in the nervous tissues. METHODS This experimental stud...