The drug-loading properties of nanocarriers depend on the chemical structures and properties of their building blocks. Here we customize telodendrimers (linear dendritic copolymer) to design a nanocarrier with improved in vivo drug delivery characteristics. We do a virtual screen of a library of small molecules to identify the optimal building blocks for precise telodendrimer synthesis using pe...

Herein, we report the use of a theranostic nanocarrier (Folate-HBPE(CT20p)) to deliver a therapeutic peptide to prostate cancer tumors that express PSMA (folate hydrolase 1). The therapeutic peptide (CT20p) targets and inhibits the chaperonin-containing TCP-1 (CCT) protein-folding complex, is selectively cytotoxic to cancer cells, and is non-toxic to normal tissue. With the delivery of CT20p to...

Phytocompounds have been used in medicine for decades owing to their potential in anti-inflammatory applications. However, major difficulties in achieving sustained delivery of phyto-based drugs are related to their low solubility and cell penetration, and high instability. To overcome these disadvantages, nanosized delivery technologies are currently in use for sustained and enhanced delivery ...

Nanocarrier-delivered dsRNA can be a promising environmentally friendly pest management solution.

We have established a tumour marker activated nanocarrier that can respond to the intracellular mRNA, allowing multimodal cancer cell imaging and therapy.

Flavonoids are polyphenolic secondary metabolites that serve a variety of purposes, from assisting pollination in plants to providing anti-cancerous activity in humans. It is the wide range of functions that give these molecules the highly revered status they have today. Range in function can be linked with the range in structure, and with over 10,000 different flavonoids known, they make up on...

Flavonoids are polyphenolic plant secondary metabolites with many purposes, including providing pigmentation in plants and anti-oxidant and anti-cancerous activities in humans. There are over 10,000 different flavonoids known, making them one of the largest groups of natural products. One major sub-class of flavonoids is the flavan-3-ols, which are known for their health benefits and the abilit...

Usage of combination therapies to deliver multiple therapeutics to increase treatment efficacy has shown promising results in the clinic. In an effort to maximize the synergistic effect of co-delivery of a drug and siRNA, we have developed a time-dependent sequential drug delivery system (DDS) based on a disulfide-linked chitosan-based nanocarrier (CS-ss-SA) for the co-delivery of paclitaxel (P...

The mucus overlying mucosal epithelial surfaces presents not only a biological barrier to the penetration of potential pathogens, but also therapeutic modalities including RNAi-based nanocarriers. Movement of nanomedicines across the mucus barriers of the gastrointestinal mucosa is modulated by interactions of the nanomedicine carriers with mucin glycoproteins inside the mucus, potentiated by t...