objective(s):in this study, we aimed at evaluation of electrophysiological and histopathalogical characteristics of statin-induced muscle injury as well as clinical features of patients who develop this condition in terms of frequency and pattern of evolution. materials and methods: forty patients (age 39-74 years) including 25 subjects with type 2 diabetes mellitus, 9 with cardiovascular disea...

background and objective: becker muscular dystrophy (bmd) is a subtype of dystrophinopathies and designated as “mild form of dystrophinopathy”. the frequency rate of the disease is 1:18000 to 1:30000 in different populations and the symptoms are presented at about 8-9 years of age. the diagnostic panel composed of serum ceratin kinase (sck) measurement, electromyography (emg), and as a major co...

We aimed to assess the reliability of the single biopsy approach for calculating muscle protein synthesis rates compared with the well described sequential muscle biopsy approach following a primed continuous infusion of L-[ring-(2)H(5)]phenylalanine and GC-MS analysis in older men. Two separate experimental infusion protocols, with differing stable isotope amino acid incorporation times, were ...

It has been well established that in several chronic diseases such as in chronic obstructive pulmonary disease (COPD), diabetes, cancer or congestive heart failure patients, next to central dysfunctions, the patients develop some systemic consequences that can lead to peripheral muscle dysfunction. Some important clinical implications such as reduced exercise capacity, reduced quality of life a...

UNLABELLED Pompe disease (PD) can be diagnosed by measuring alpha-glucosidase levels or by identifying mutations in the gene enzyme. Muscle biopsies can aid diagnosis in doubtful cases. METHODS A review of muscle biopsy from 19 cases of PD (infantile, 6 cases; childhood, 4 cases; and juvenile/adult, 9 cases). RESULTS Vacuoles with or without glycogen storage were found in 18 cases. All case...

Several drugs and toxic substances can cause muscular abnormalities and are frequent causes of acquired myopathies. We present a series of 32 patients, predominance of young adult patients, diagnosed with toxic myopathy. The most common substances inducing myopathy were corticosteroids (56.2%) followed by the propoxyphene, neuroleptics, zidovudine and drug-induced hypokalemia. The investigation...

S U M M A R Y — T o f ind w h a t the cor re la t ion is and ver i fy if is poss ib le to avo id ex tens ive e l ec t romyograph i c examinat ion , s t udy ing o n l y one muscle, 100 patients w i th neuromuscu la r d i sorders (58 p r imary myopa th ie s , 32 neu rogen ic d i sorders and 10 m y o t o n i c dys t roph ies ) w e r e submi ted to quant i f ied e l e c t r o m y o g r a p h y ( E ...