OBJECTIVES To improve the level of 'definitive' diagnosis of Langerhans cell histiocytosis by immunohistochemical investigation of the CD1a surface antigen and to compare outcomes in respect to age, gender, stage of the disease, treatment response and level of diagnostic accuracy. METHODS A retrospective study was carried out of 37 children and adolescents with possible Langerhans cell histio...

During the Coronavirus disease 2019 (COVID-19) pandemic, children are less affected than adults, and underlying conditions and older age are associated with severe disease. Following the SARS-CoV-2 pandemic, outbreaks of cases with Kawasaki-like disease and a few others with the multisystem inflammatory syndrome in children related to COVID-19 (MIS-C) have been reported. Here, we report a two-y...

Multisystem inflammatory syndrome in adults (MIS-A) came to attention back June 2020, when the United States Center for Disease Control and Prevention (CDC) received initial reports regarding patients who had presented delayed multisystem involvement of disease, with clinical course resembling children (MIS-C). This study introduces a case MIS-A, where patient 3 weeks after COVID-19 exposure. H...

Crohn’s disease (CD) encompasses a multisystem group of disorders with specific clinical and pathological features characterized by focal, asymmetric, transmural, and, occasionally, granulomatous in flammation primarily affecting the gastrointestinal (GI) tract. It is a multisystem disorder with potential for systemic and extra-intestinal complications (1) that can affect any age group, but the...

Tuberculosis is an infectious disease widely spread around the world and leading cause of death among people living with human immunodeficiency virus (HIV). Multisystem tuberculosis occurs more frequently in patients HIV coinfection, its clinical presentation may be related to patient’s immunosuppression level. We report case a 19-year-old male patient due unusual multisystem affecting respirat...

BACKGROUND Short sleep and poor sleep quality are associated with risk of cardiovascular disease, diabetes, cancer, and mortality. This study examines the contribution of sleep duration and sleep quality on a multisystem biological risk index that is known to be associated with morbidity and mortality. METHODS Analyses include a population-based sample from the Midlife Development in the Unit...

A small subset of pediatric patients develop a newly emerging syndrome associated with post COVID-19 infection. Termed Multisystem Inflammatory Syndrome in Children (MIS-C), this shares characteristics Kawasaki Disease (KD), including fever, elevated inflammatory markers and multisystem involvement (cardiac, neurological, ocular, dermatological, mucocutaneous gastrointestinal). MIS-C can have m...

Background Chronic progressive multisystem granulomatous disease is seen in 10–30% of patients with sarcoidosis and can result in end organ damage [1]. Corticosteroids are the mainstay of treatment with the addition of cytotoxic agents in severe cases. Some patients are refractory to such treatment and therefore management is a challenge. There is currently limited evidence for biological agent...