BACKGROUND Müllerian inhibiting substance, produced constitutively by the prepubertal testes, promotes involution of the müllerian ducts during normal male sexual differentiation. In children with virilization and nonpalpable gonads, only those with testicular tissue should have detectable serum concentrations of müllerian inhibiting substance. METHODS We measured serum mullerian inhibiting s...

THE DEVELOPMENT OF THE MAMMALIAN REPRODUCTIVE SYSTEM INVOLVES: (1) an indifferent or ambisexual stage, in which both the male (Wolffian) and female (Mullerian) duct systems are present; (2) sexual differentiation, in which the phenotypic sex is expressed by the enhancement of Mullerian structures in the female and Wolffian structures in the male and reciprocal suppression of the opposite duct s...

Abstract Background Septate uterus is a common Mullerian ducts anomaly. The aim of our pilot study was the evaluation diode laser hysteroscopic metroplasty efficacy to increase endometrial volume in women with septate uterus. Results We prospectively enrolled 10 consecutive patients undergoing office between February and November 2019. Endometrial evaluated before 3 months after surgery using 3...

ullerian duct anomalies (MDAs) are relatively common disorders that are particularly responsible for obstetrical complications and have a prevalence of about 3%−4% in the general population (1, 2). Uterine malformations may result from arrested development of the mullerian ducts, failure of fusion of the mullerian ducts or failure of resorption of the median septum (1, 2). Several classificatio...

Obstructed hemivagina and ipsilateral renal anomaly (OHVIRA) syndrome is a characterised by obstructed hemivagina, agenesis uterine didelphys. It rare congenital results from defective fusion of the Müllerian ducts during development female reproductive system. also known as Herlyn-Werner-Wunderlich syndrome. Aim study was to project case developmental Mullerian OHVIRA anomaly. The most common ...

Anti-Mullerian hormone (AMH) is mainly involved in the regression of Mullerian ducts in male fetuses, but it may have other functions linked to gonadal development. The present study examines the effect of AMH on steroidogenesis by Sertoli and Leydig cells in fetal and immature rats during the period where AMH is physiologically produced in the testis. The basal aromatase activity of Sertoli ce...

Background: Mayer - Rokitansky - Kuster - Hauser (MRKH) syndrome is characterized by congenital aplasia of the uterus and the upper part of the vagina in women showing normal development of secondary sexual characteristics and a normal 46, XX karyotype. Congenital anomaly of the female genital tract, estimated to occur in approximately 1 in every 5,000 females. It is caused by a failure of deve...

Mullerian Inhibiting Substance (MIS), a biological modifier that causes regression of Mullerian ducts in male embryos, is effective as a single agent in vitro and in vivo against human and mouse ovarian cancer cell lines expressing MIS type II receptor; however, little is known about how recombinant human MIS (rhMIS), now being scaled for preclinical trials, could be used in combination with cy...

Anti mullerian hormone (AMH) is a homodimeric glycoprotein belonging to the transforming growth factors (TGF-β) super family. AMH plays a fundamental role in the regression of mullerian ducts in male embryo. In boys, it is significantly produced in Sertoli cells of testes until puberty and then slowly decreases to residual values for the rest of the men’s life. In female, it is secreted by gran...