A 34 year old woman presented with primary infertility and duplication of the cervix and vagina. Laparoscopy demonstrated a normal uterus and hysterosalpingography revealed a normal uterine cavity communicating with both cervices. This rare Mullerian anomaly is inconsistent with our current understanding of Mullerian development. An alternative embryological mechanism is reviewed to account for...

A bicornuate uterus is a rare mullerian duct anomaly (MDA) caused by fusion defects of the mullerian duct during embryogenesis.1 They are of clinical significance because they can result in fertility problems ranging from infertility and recurrent abortions to prematurity and malpresentation which increases the perinatal morbidity and mortality rate2. In this paper a case is presented to highli...

Herlyn-Werner-Wunderlich syndrome also known as uterus didelphys with obstructing hemivaginal septum and ipsilateral renal agenesis is a rare syndrome with only a few hundred reported cases described since 1922. Uterus Didelphys is a type of lateral fusion disorder of mullerian ducts. Mullerian duct anomalies have an incidence of 2–3%, while obstructing hemivaginal septum and ipsilateral renal ...

Mutations were introduced into conserved steroidogenic factor 1 (SF1)- and SOX9-binding sites within the endogenous mouse Mullerian inhibiting substance (Mis) promoter. Male mice homozygous for the mutant SF1-binding site correctly initiated Mis transcription in fetal testes, although at significantly reduced levels. Surprisingly, sufficient MIS was produced to eliminate the MUllerian ducts. In...

Persistent Mullerian Duct Syndrome (PMDS), a rare form of male pseudohermaphroditism, is characterized by the persistence of Mullerian duct structures (uterus, fallopian tubes and upper two-thirds of vagina) in otherwise normallyvirilized males (Karyotype 46XY). Patients suffering from PMDS present with cryptorchidism, inguinal hernia and infertility. Diagnosis is established when Mullerian duc...

Only five cases of recurrence of malignant mixed Mullerian tumor (carcinosarcoma) from the ovarian carcinoma have been published in the literature to our knowledge. A 64-year-old woman first underwent a total abdominal hysterectomy and bilateral salpingo-oophorectomy because of pelvic mass. Histological diagnosis was serous papillary carcinoma of the left ovary. After six courses of chemotherap...

Bicornuate Uterus is a type of lateral fusion disorder of the mullerian ducts. According to the American Fertility Society Classification of Mullerian Anomalies, bicornuate uterus is a class IV anomaly. Incidence of this anomaly varies. This may affect a woman's obstetric, as well as her gynecologic outcome. Here we present a 23 year primigravida at 38 weeks and 5 days gestation with footling b...

INTRODUCTION Persistent Mullerian duct syndrome (PMDS) is a rare type of pseudohermaphroditism in genotypically and phenotypically males. They have a uterus, fallopian tubes, and upper part of the vagina; but Mullerian duct fails to regress. In transverse testicular ectopia (TTE), one of the testis moves to the opposite side and both testes pass the same inguinal canal. We report a case of PMDS...

Mullerian adenosarcoma of the cervix is a rare tumor composed of benign epithelial and malignant stromal components. Sarcomatous overgrowth and heterologous elements in cervical adenosarcoma are extremely infrequent. We report the case of a 26-year-old woman admitted at the gynaecology department for a painless mass protruding from her vagina. The initial pathological exam concluded to endocerv...